S174 Poster presentations MON-PP123 MAINTAINING PHYSICAL ACTIVITY DURING REFEEDING MAY LIMIT ANXIETY IN ANORECTIC MICE BY INCREASING THE MUSCLE METABOLISM OF KYNURENINE N. Achamrah 1 , C. Bˆ ole-Feysot 1 , S. Nobis 1 , L. Belmonte 1 , A. Goichon 1 , J.L. Do Rego 2 , J.C. Do Rego 3 , P. D´ echelotte 1 , M. Co¨ effier 1 . 1 INSERM unit 1073, Institute for Research and Innovation in Biomedicine, 2 Institute for Research and Innovation in Biomedicine, 3 Animal Behavior Platform SCAC, Institute for Research and Innovation in Biomedicine, Rouen University, Rouen, France Rationale: The influence of adapted physical activity during refeeding in patients with anorexia nervosa (AN) remains de- bated. Recent data suggest a role of physical activity-altered kynurenine pathway in the well-being. We investigated the effects of physical activity during refeeding in the activity- based anorexia model (ABA). Methods: C57Bl/6 male mice were placed in calorimetric cages equipped with a running wheel. Mice had a progressively limited access to food until day 17. Ad libitum food access was restored at day 17 and mice were divided into two subgroups: with physical activity (ABA-PA, n = 4) and without physical activity (ABA-NPA, n = 4). Energy expenditure (EE) and Respiratory Exchange Ratio (RER) were continuously monitored. After body weight restoration, soleus muscles were taken and factors involved in kynurenine metabolism were analyzed by qPCR. ANOVA or t test were used, p < 0.05 was considered significant. Results: Body weight loss was about 25% at day 17. After refeeding, body weight was restored at day 22. ABA-PA, but not ABA-NPA mice, completely restored fat free mass (p < 0.05). A fat mass rebound was observed in both groups. During the first day of refeeding, RER was higher in ABA- NPA than in ABA-PA (approximately 1.1, p < 0.05). EE was reduced in ABA mice at day 17 (p < 0.05) but was rapidly restored during refeeding. At day 22, ABA-PA mice had higher EE than in ABA-NPA mice (p < 0.05). Horizontal locomotor activity was decreased at day 17 and restored only in ABA- PA mice, suggesting anxiety in ABA-NPA mice. KAT3, KAT4 and PPARd mRNA levels were increased in soleus muscle of ABA-PA compared with ABA-NPA (p < 0.05), suggesting the metabolism of kynurenine into kynurenic acid. Conclusion: Maintaining physical activity during refeeding allows better fat free mass restoration and may limit anxiety in ABA mice by increasing the muscle metabolism of kynurenine. Disclosure of Interest: None declared MON-PP124 YOUTUBE’S FOOD, DIET-RELATED ITEMS & ADVISORY COMMENTS (FODRIACS) FOR INFLAMMATORY BOWEL DISEASE (IBD) MANAGEMENT N. Tsopela 1 , V. Svolos 1 , R.K. Russell 2 , K. Gerasimidis 1 . 1 Human Nutrition, School of Medicine, University of Glasgow, 2 Paediatric Gastroenterology, Royal Hospital for Sick Children, Glasgow, Glasgow, United Kingdom Rationale: Diet is a proven IBD risk factor and dietetic therapy a primary treatment for Crohn’s disease (CD); thus, patients often seek IBD management alternatives via internet resources. This cross-sectional study explored FODRIACs presented on YouTube for IBD management. Methods: A YouTube search was performed using all com- binations of the terms food, diet and nutrition with IBD, CD and Ulcerative colitis (UC), filtered by relevance, views and rating. The first 25 relevant videos from each search were selected. The most common FODRIACs (mentioned in 30 videos), disease they were addressed for and speaker classification, were identified. Video content was categorised according to its inference to IBD clinical management. Results: 203 videos were selected; 95% did not cite any scientific evidence. 50% came from patients/relatives while 29% from healthcare professionals. The most common FO- DRIACS (total = 169) were dairy, vegetables, fibre, Specific Carbohydrate Diet (SCD), fruit and sugars (n = 45; 34; 32; 32; 31; 30 videos respectively). The SCD, Gluten Free (GF) diet, multivitamins/minerals, probiotics and n-3 supplements received no negative, whereas dairy and high-fat foods received no positive remarks. Views on fibre were mixed. SCD and probiotics were mostly supported for CD than for UC; the opposite applied for GF diet. Almond milk, honey, lean meat, aloe, food journal use, food intolerance testing, digestive enzymes and low-fat, GF, healthy, organic/raw diets were the main FODRIACs proposed for maintenance of remission (80% of videos). Fizzy drinks, wheat, red meat, acidic, processed and spicy foods were the main relapse triggers (80% of videos). Conclusion: Anecdotal evidence reinforces YouTube claims but scientific evidence does not support the majority of items. Dietary interventions hold a promising role in IBD management but further studies are required to make robust recommendations. Disclosure of Interest: None declared MON-PP125 THE ASSOCIATION BETWEEN SERUM ADIPONECTIN LEVELS AND METABOLIC SYNDROME COMPONENTS IN PATIENTS WITH METABOLIC SYNDROME N. Goren Atalay 1 , B. ¸ Ci¸cek 2 , G.G. ¨ Or¨ uk 1 , M. Bah¸ceci 3 . 1 Endocrinology and Metabolism Department, ˙ Izmir Katip ¸ Celebi University Ataturk Education and Research Hospital, ˙ Izmir, 2 Department of Nutrition and Dietetics, Erciyes University Faculty of Health Science, Kayseri, 3 Endocrinology and Metabolism Department, Kent Hospital, ˙ Izmir, Turkey Rationale: it was aimed to determine the association between adiponectin levels and metabolic syndrome (MetS) components besides food consumption and anthropometric indices in patients with MetS Methods: 137 patients diagnosed with MetS according to IDF criteria and age- and gender-matched 51 healthy controls aged between 18 65 years were included. Sociodemographic data and food consumption records were taken. Serum adiponectin and biochemical parameters were measured. Body weight, height, circumference measurements from seven sites, skinfold thickness from five sites were measured and body mass index was calculated. Bioelectrical impedance analysis was used to evaluate body fat weight, body fat percentage. Individual diets were planned according to MetS components and the participants were followed for three months. All the biochemical and anthropometric indices were repeated for pre- and post-diet periods.