RESEARCH ARTICLE Am. J. PharmTech Res. 2015; 5(4) ISSN: 2249-3387 Please cite this article as: Mohanty C et al., Use of Sintering Technique to Sustain the Release of Atazanavir Sulphate from Gastro Retentive Floating Matrix Tablets. American Journal of PharmTech Research 2015. Use of Sintering Technique to Sustain the Release of Atazanavir Sulphate from Gastro Retentive Floating Matrix Tablets Chandan Mohanty 1 *, K V Subrahmanyam 2 , Tapan Kumar Jena 3 , Devarashetti Sreekanth 4 1. St. Mary’s Pharmacy college, Deshmukhi (V), Pohamplly (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telengana, India 2. Samskruti college of Pharmacy, Kondapur (V) Ghatkesar (M), RR Dist, Telengana, India 3. DR. Reddy’s Laboratories ltd, Bachupally, RR Dist, Telengana, India. 4. Deevena College of Pharmacy, Chivemla, Suryapet, Nalgonda (Dist), Telengana, India. ABSTRACT The concept of the sintering technique in the pharmaceutical sciences is relatively new.The objective of the present study was to prepare and evaluate thermally sintered gastro retentive floating matrix tablets of Atazanavir sulphate. The formulations were prepared by direct compression method using EC N100 and HPMC K100 as polymer. The prepared tablets were exposed at two different temperatures like 50 0 C and 60 0 C for two different periods like 1.5 hr and 3 hr in a hot air oven. Effects of sintering conditions were studied on in vitro dissolution studies, hardness, friability, floating lag time and total floating time. The sintering temperature and the sintering time markedly affected the drug release properties. The release rate of the drug was inversely related to the sintering temperature and the sintering time. The hardness was increased with increase in sintering temperature and duration of sintering; but friability of tablets was found to be decreased with increasing sintering time. Floating lag time was inversely proportional to the sintering temperature and sintering time, whereas total floating time was directly proportional to the sintering temperature and sintering time. The formulation F2 sintered at 60 0 for 3 h was selected as an optimized formulation based on the drug retarding properties and the optimized formulation followed Fickian diffusion mechanism with Korsmeyer-Peppas release kinetics. FTIR and DSC studies were used to characterize the optimized formulation and those studies showed no evidence on interaction between the drug and polymer used. Keywords: Sintering, Gastro retentive, Floating, Atazanavir sulphate (ATZ). *Corresponding Author Email: chandan_mohanty31@rediffmail.com Received 25 July 2015, Accepted 30 July 2015 Journal home page: http://www.ajptr.com/