International Journal of Medical Science in Clinical Research and Review Online ISSN: 2581-8945 Available Online at http://www.ijmscrr.in Volume 7|Issue 02 (March-April) |2024 Page: 385-390 IJMSCRR: March-April 2024 https://doi.org/10.5281/zenodo.11069572 Page | 385 © R. Nemmar et al. Case Report Synovialosarcoma of the hand About 03 cases. Authors: R. Nemmar 1 , A. Mohand Oussaid 1 , M. Derradji 1 , Kamel Hail 1 , Kerboua Esma 2 , Meskouri Karim 1 , Benyahia Radia 2 Department of orthopaedics and traumatology CHU Mustapha Algiers’s Faculty of medecine Department of orthopaedics and traumatology CHU Mustapha Algiers’s Faculty of medecine Department of orthopaedics and traumatology CHU Mustapha Algiers’s Faculty of medecine Oncology department Pierre Marie Curie center Hail Kamel department of visceral surgery CHU Mustapha Faculte de medecine d'Alger Meskouri Karim department of thoracic surgery CHU Mustapha Alger Faculte de medecine d'Alger Radiology department, Pierre Marie Curie center Corresponding Author: R. Nemmar Article Received: 13-March-2024, Revised: 03-April-2024, Accepted: 23-April-2024 ABSTRACT: Synovialosarcoma is a rare tumor. It accounts for 8-10% of malignant soft-tissue tumors and around 10% of malignant soft-tissue tumors in the hand (2,4,8,9,11). Its prognosis is the most severe of all soft-tissue sarcomas, with around 50% recurrence within two years and an estimated survival of 50% at 5 years, and 25% at 10 years (1,9). Conservative surgery of the hand and wrist is indicated according to tumor extension and affected compartment. Material and methods: The authors report three cases of synovialosarcoma of the hand. The patients were 28, 32 and 37 years old. Two patients were female. Diagnosis was late in all cases. Extension work-up included standard chest X-ray, MRI and thoraco-abdomino- pelvic CT scan. In all three cases, the clinical presentation was different: Keywords: Synovialosarcoma, malignant soft-tissue tumors, thoraco-abdomino-pelvic CT scan CASE REPORT: A: The first patient, Miss A, aged 28, presented with a 2cm swelling on the palmar surface of the right hand (right- handed patient), which had appeared 6 months previously. The CT scan showed a tumor opposite the palmar surface of the diaphysis of the 4th metacarpal (fig 1). Extension workup revealed no other localization. A palmar biopsy showed a monophasic synovialosarcoma with an R1 resection margin, i.e. microscopically incomplete. As the palmar resection was incomplete, a dorsal amputation was performed, removing the 4th metacarpal bone (Fig. 2), followed by reconstruction of the 4th radius with a cortico-cancellous tibial bone graft (Fig. 3). Adjuvant chemotherapy was performed. Local and pulmonary metastases appeared one year later, resulting in the patient's death. Fig1: Horizontal section through the diaphysis of the metacarpals.