Accepted Manuscript Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpho- lino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN- deficient tumours Bernard Barlaam, Sabina Cosulich, Sébastien Degorce, Rebecca Ellston, Martina Fitzek, Stephen Green, Urs Hancox, Christine Lambert-van der Brempt, Jean-Jacques Lohmann, Mickaël Maudet, Rémy Morgentin, Patrick Plé, Lara Ward, Nicolas Warin PII: S0960-894X(17)30262-7 DOI: http://dx.doi.org/10.1016/j.bmcl.2017.03.027 Reference: BMCL 24779 To appear in: Bioorganic & Medicinal Chemistry Letters Received Date: 13 February 2017 Revised Date: 9 March 2017 Accepted Date: 12 March 2017 Please cite this article as: Barlaam, B., Cosulich, S., Degorce, S., Ellston, R., Fitzek, M., Green, S., Hancox, U., Lambert-van der Brempt, C., Lohmann, J-J., Maudet, M., Morgentin, R., Plé, P., Ward, L., Warin, N., Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours, Bioorganic & Medicinal Chemistry Letters (2017), doi: http:// dx.doi.org/10.1016/j.bmcl.2017.03.027 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.