Journal of Perinatology
https://doi.org/10.1038/s41372-018-0154-3
ARTICLE
Transcutaneous bilirubinometer use and practices surrounding
jaundice in 150 California newborn intensive care units
Dilip R. Bhatt
1
●
Alexandria I. Kristensen-Cabrera
2
●
Henry C. Lee
2
●
Sunjeeve Weerasinghe
1
●
David K. Stevenson
2
●
Vinod K. Bhutani
2
●
M. Jeffrey Maisels
3
●
Rangasamy Ramanathan
4
Received: 5 September 2017 / Revised: 10 April 2018 / Accepted: 17 May 2018
© Nature America, Inc., part of Springer Nature 2018
Abstract
Objectives Transcutaneous bilirubin measurements (TcBs) provide a noninvasive method for screening infants for hyper-
bilirubinemia and have been used extensively in term and late preterm newborns in well baby nurseries, offices, and
outpatient clinics. Several studies have also demonstrated the utility of TcBs as a screening tool for infants > 28 weeks’
gestation and their ability to reduce the need for blood sampling. The objectives of this study are to identify how often TcBs
are used among California Newborn Intensive Care Units (NICUs) in preterm, late preterm and term infants, and other
aspects of jaundice management.
Methods We conducted a survey on TcB use and practices relating to jaundice management in 150 California NICUs
between April and October 2016.
Results TcB screening is routinely used in 28% (42/150) of NICUs. Only 7% (11/150) of NICUs use TcB in preterm infants
< 28 weeks. Practice varied similarly across NICU levels of care. Among the subset of NICUs that responded to questions
related to phototherapy and screening practices, prophylactic phototherapy was used in 38% (23/59) and 90% (55/61)
screened for glucose-6-phosphate dehydrogenase deficiency based on race, ethnicity, and/or family history.
Conclusion(s) Despite studies validating the accuracy of TcB in preterm infants > 28 weeks, only 28% of California NICUs
routinely use TcB devices. TcB screening in infants < 28 weeks gestation is not widely used and no recommendation can be
made in this regard until there is more experience with its application using a standardized protocol in these infants and on a
large scale.
Introduction
Transcutaneous bilirubinometers (TcBs) provide a non-
invasive, pain-free, rapid estimation of bilirubin levels [1].
When used as a screening technique that tells the caretaker
when to obtain a total serum bilirubin (TSB), TcBs have
been shown to reduce the need for blood sampling, improve
patient safety, decrease resource utilization, and decrease
the need for phototherapy [2–4].
The 2004 hyperbilirubinemia guideline of the Amer-
ican Academy of Pediatrics (AAP) and the update in 2009
recommended the use of TcBs for infants > 35 weeks’
gestation [5, 6], but the “consensus-based” recommenda-
tion for the management of hyperbilirubinemia in preterm
infants < 35 weeks did not mention TcBs [7]. In term
infants, a consistently strong correlation has been shown
between TcB and TSB levels [8, 9] and a systematic
review concluded that TcB devices provide a reliable
estimate of TSBs in preterm infants [10]. The use of TcBs
in infants receiving phototherapy remains controversial
[11, 12]. Although there is a moderate correlation between
TcB and TSB during phototherapy, TcB levels are con-
sistently lower than TSB values during phototherapy [13].
Because we do not know how TcB devices are currently
utilized in NICUs, we sought this information from
California NICUs.
* Dilip R. Bhatt
dilip.r.bhatt@kp.org
1
Pediatrics Department- Neonatology, Kaiser Permanente,
Fontana, CA, United States
2
Pediatrics, Stanford University, Stanford, CA, United States
3
Pediatrics, Oakland University William Beaumont School of
Medicine and Beaumont Children’s, Royal Oak, MI, United States
4
Pediatrics- Division of Neonatology, LAC+USC Medical Center,
Keck School of Medicine of USC, Los Angeles, CA, United States
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