MATTER: International Journal of Science and Technology ISSN 2454-5880 Available Online at: http://grdspublishing.org/ 1 Ramasamy & Khoo, 2019 Volume 5 Issue 2, pp. 01-19 Date of Publication: 15th July 2019 DOI-https://dx.doi.org/10.20319/mijst.2019.52.0119 This paper can be cited as: Ramasamy, G. & Khoo, E. H. (2019). Chıral Woodpıle Morphology Optımızatıon for Plasmonıc Enhanced Enantıomerıc Detectıon ın Pharmacology Qualıty Management. MATTER: International Journal of Science and Technology, 5(2), 01-19. This work is licensed under the Creative Commons Attribution-Non Commercial 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc/4.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA. CHIRAL WOODPILE MORPHOLOGY OPTIMIZATION FOR PLASMONIC ENHANCED ENANTIOMERIC DETECTION IN PHARMACOLOGY QUALITY MANAGEMENT Gautam Ramasamy Anglo-Chinese School (International) Singapore, Institute of High Performance Computing, A*STAR (Agency for Science, Technology and Research), Republic of Singapore gautam.ramasamy@acsinternational.com.sg Eng Huat Khoo Electronics and Photonics Department, Institute of High Performance Computing, A*STAR (Agency for Science, Technology and Research), National University of Singapore, Nanyang Technological University (Singapore), Harvard University (United States), Republic of Singapore khooeh@ihpc.a-star.edu.sg Abstract The majority of pharmaceuticals currently in circulation are chiral compounds; mostly sold as equimolar mixtures of two enantiomers. Albeit, they have identical chemical structures, the human body metabolizes each enantiomer by separate pathways due to their different handedness. Hence, one isomer may exhibit the intended pharmaceutical effect, whereas the other exists as an inactive impurity or, occasionally, may engender undesirable side-effects and toxicity, like in the Softenon disaster which caused circa one thousand congenital disabilities (International Union of Crystallography, 2016). Therefore, it is imperative to promote chiral separation and analysis of chiral drugs in pharmaceutical manufacture to eliminate the undesirable enantiomer (Nguyen, He, & Pham-Huy, 2006).