MO124 INTRADIALYTIC SYMPTOMATOLOGY IS LARGELY PATIENT-SPECIFIC IN BOTH HAEMODIALYSIS AND HAEMODIAFILTRATION: A RANDOMIZED CROSS-OVER TRIAL BETWEEN FOUR INTERMITTENT DIALYSIS MODALITIES Gertrude Wijngaarden 1 , Paul A Rootjes 2 , Camiel de Roij van Zuijdewijn 2 , Menso J. Nubé 2 and Muriel Grooteman 2 1 Department of Nephrology and Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, locatie AMC, VU University, Amsterdam, The Netherlands, and 2 Department of Nephrology and Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, locatie AMC, VU University, Amsterdam, The Netherlands BACKGROUND AND AIMS: Standard haemodialysis is associated with a considerable burden of intradialytic symptoms. Although haemodialysis with cool dialysate is associated with less intradialytic discomfort in general, the incidence of cold sensations increases significantly. Whether treatment with online post-dilution high-volume haemodiafiltration [target convection volume (CV) ≥23 L/session] reduces adverse intradialytic symptoms and provokes cold sensations is unknown. METHOD: We performed a randomized controlled cross-over trial in 40 prevalent dialysis patients, who were subjected to two haemodialysis modalities: standard haemodialysis [sHD; dialysate temperature (Td) of 36.5°C] and cool haemodialysis (cHD; Td 35.5°C) and two haemodiafiltration modalities: low-volume haemodiafiltration (lvHDF, CV 15 L/1.73 m 2 /session, Td 36.5°C) and high-volume haemodiafiltration (hvHDF, CV ≥23 L/1.73 m 2 /session, Td 36.5°C). Every dialysis modality lasted 2 weeks. Intradialytic symptoms were evaluated after the last session of each dialysis modality, with a slightly modified Dialysis Symptom Index (mDSI). Intradialytic thermal sensations were scored on the Visual Analogue Scale Thermal Perception (VAS-TP) before and after 1 and 3 h of each treatment session. Patients were trained to use the mDSI and VAS-TP, in order to reduce incidental stress and unwanted learning responses due to the trial environment. Repeated measures analysis of variance (ANOVA) and one-way ANOVA were used to measure potential differences in intradialytic symptoms between the dialysis modalities (intraindividual differences) and to assess potential interindividual differences in intradialytic symptoms. Linear mixed models with an interaction term between time and modality were used to determine differences in rate of change of VAS-TP between the four modalities. When appropriate, stratified models were fitted subsequently. RESULTS: With the exception of cold sensations during cHD (P = .01), intradialytic symptoms did not differ between modalities, but varied markedly between patients (P < .05 in 11/13 items, Table 1). While the VAS-TP score remained unaltered in sHD, lvHDF and hvHDF, patients felt significantly more cold sensations during cHD (P = .007)(Figure 1). Stratified models showed a decrease of 0.43 points/h on the VAS-TP scale (P = .007) in the first hour of cHD and remained unaltered thereafter [+0.10 points/h (P = .20)]; thermal perception remained unaltered [0.04 points/h (P = .77)] in the other modalities. CONCLUSION: Intradialytic symptomatology was, except for the symptom feeling cold, by and large similar in all modalities, but it varied markedly between patients. Hence, adverse intradialytic symptoms seem largely patient-specific. Patients experienced more cold sensations during cool HD, but not during haemodiafiltration. FIGURE 1: Intradialytic change of thermal perception. Visual Analogue Scale Thermal Perception (VAS-TP: 3.5–5.0 = cold—neutral; 5.0–6.0 = neutral—slightly warm. MO125 ASSOCIATION OF BLADDER POST-VOID RESIDUAL VOLUME AND URINARY TRACT INFECTION IN ADULT FEMALES Natalie Maramba, Fayanne Patricia Lim and Jennifer Leano Internal Medicine, San Pedro Hospital of Davao City, Inc., Davao City, The Philippines BACKGROUND AND AIMS: Urinary retention is the inability to voluntarily pass a sufficient amount of urine [1]. This predominantly affects males often due to benign prostatic hyperplasia [1]. In patients with symptomatic urinary retention, initial management such as urethral catheter insertion is warranted, along with further investigation. Multiple complications due to urinary retention include electrolyte imbalance, UTI and renal failure [2, 3]. Prognosis is fair if recognized early and subsequently treated [3]. Currently, there is a lack of standardization in studies involving post-void residual and urinary retention in females [4]. Hence, the aim of this study was to determine if there is a significant association between post-void residual volume estimated by sonography and UTI in symptomatic and asymptomatic adult females. Furthermore, the aim of this study was also to determine the residual volume detected in females with UTI and to describe the patients in terms of age, menopausal status, comorbids and genitourinary profile. METHOD: The study was a retrospective case-control design with purposive sampling conducted in San Pedro Hospital, Inc., Davao City, Philippines. It involved 430 adult females aged 19 years and above who were admitted from 2018 to 2021 with urinalysis and/or urine culture as well as a pre- and post- void scan result. Factors included that may contribute to UTI were age, presence or absence of diabetes, menopause, hypertension, cerebrovascular accident and anatomic abnormalities and were compared in terms of incidence of UTI between groups. In terms of overall Table 1. Frequencies of reported intradialytic symptoms Symptom sHD n = 38 cHD n = 38 lvHDF n = 37 hvHDF n = 37 Differences between modalities Differences between patients Dizziness 10 (26.3%) 8 (21.0%) 10 (27.0%) 8 (21.6%) P = .64 P = .03 Nausea 3 (7.9%) 1 (2.6%) 4 (10.8%) 2 (5.4%) P = .57 P = .03 Vomiting 2 (5.2%) 0 0 0 n/a P = .65 Headache 12 (31.6%) 8 (21.0%) 9 (24.3%) 8 (21.6%) P = .77 P < .0005 Muscle cramps 17 (44.7%) 13 (34.2%) 17 (46.0%) 15 (40.5%) P = .78 P < .0005 Swelling of the legs 6 (15.8%) 4 (10.5%) 3 (8.1%) 4 (10.8%) P = .29 P < .0005 Shortness of breath 5 (13.1%) 4 (10.5%) 8 (21.6%) 3 (8.1%) P = .26 P = .04 Chest pain 3 (7.9%) 2 (5.2%) 4 (10.8%) 2 (5.4%) P = .44 P = .51 Itching 15 (39.5%) 11 (29.0%) 17 (46.0%) 10 (27.0%) P = .26 P < .0005 Feeling cold 19 (50.0%) 25 (65.8%) 19 (51.3%) 16 (43.2%) P = .01 P < .0005 Shivering 7 (18.4%) 11 (29.0%) 8 (21.6%) 7 (18.9%) P = .80 P < .0005 Feeling tired or lack of energy 18 (k47.4%) 22 (57.9%) 19 (51.3%) 22 (59.4%) P = .70 P < .0005 Recovery time 30 (79.0%) 28 (73.7%) 27 (73.0%) 31 (83.7%) P = .90 P < .0005 Abstract i73 Downloaded from https://academic.oup.com/ndt/article/37/Supplement_3/gfac066.027/6578567 by guest on 18 February 2024