Freely Available Online www.openaccesspub.org | JVHC CC-license DOI : 10.14302/issn.2575-1212.jvhc-17-1764 Vol-1 Issue 2 Pg. no.- 1 JOURNAL OF VETERINA RY HEALTH CARE ISSN NO: 2575-1212 RESEARCH ARTICLE L.Miguel Carreira 1, 2, 3* , P. Monteiro 1 ; Pedro Azevedo 1 1. Anjos of Assis Veterinary Medicine Centre (CMVAA), Rua D.ª Francisca da Azambuja Nº9 -9A- Barreiro, Portugal 2 .Faculty of Veterinary Medicine, University of Lisbon (FMV/ULisboa), Av. da Universidade Técnica de Lisboa, 1300-477 Lisbon, Portugal, 3 . Centre for Interdisciplinary Research in Animal Health (CIISA), FMV/ULisboa, Av. da Universidade Técnica de Lisboa, 1300-477 Lisbon, Portugal, Abstract Leishmaniasis treatment monitoring is an important problem, since patient ’s frequently present clinical signs improvements with positive indirect immunofluorescence (IFI) titers of anti-Leishmania antibodies, thus making difficult the clinician understand the therapy efficacy. The study aimed 1) to identify over a short period of 30 days, which of the main changes on the serum proteinogram fractions in patients treated with meglumine antimoniate and allopurinol, can be pointed as indicator to classify patients as slower or faster responsive to treatment. A sample of 56 dogs (n=56) with leishmaniasis diagnosis was followed-up for clinical condition, proteinograms and titers of anti-Leishmania antibodies during the treatment period considering three different time points: M0 (diagnosis moment), M1 (15 days after therapy start), and M2 (30 days after therapy start). Two groups of patients were considered according to their clinical condition evolution rate: faster recovery group (FRG) and slower recovery group (SRG). Statistical significant results were considered for p-value <0.05. Statistically significant differences in proteinogram variations between FRG and SRG were registered for TPs (p= 0.03), and for the fractions β (p=0.04), γ (p=0.04), amongst M0 and M2.The PT, β and γ-globulin fractions of proteinogram, in association with patient clinical assessment evolution should be considered as an indicator and a simple way to appoint the efficacy response of the patients to the therapy. DOI :10.14302/issn.2575-1212.jvhc-17-1764 Total Proteins, β- and γ-globulins as efficacy therapy response indicators in dogs infected with Leishmania infantum – a Review Corresponding author: L.Miguel Carreira, Professor of Surgery I and II, Faculty of Veterinary Medicine, Uni- versity of Lisbon (FMV/ULisboa), Av. da Universidade Técnica de Lisboa, 1300-477 Lisbon, Portugal. email: miguelcarreira@fmv.ulisboa.pt, Tel: +351213652893 Running title: Indicators of patient efficacy therapy response to Leishmaniasis Keywords: Dog; Leishmaniasis; Proteinogram; Therapy; Patient; Prognosis Received: Sep 11,2017 Accepted: Oct 24,2017 Published: Nov 01.2017