Middle-East Journal of Scientific Research 12 (3): 392-396, 2012 ISSN 1990-9233 © IDOSI Publications, 2012 DOI: 10.5829/idosi.mejsr.2012.12.3.1062 Corresponding Author: Saman Sotoudeh, Department of Chemical Engineering, Faculty of Engineering, Arak University, Arak 38156-8-8349, Iran. Tel: +98-9183681821. 392 Antibiotic Release Process from Hydrogel Nano Zeolite Composites Saman Sotoudeh, Aboulfazl Barati, Reza Davarnejad and Mohammad Aliabadi Farahani 1 1 1 2 Department of Chemical Engineering, Faculty of Engineering, 1 Arak University, Arak 38156-8-8349, Iran Department of Chemical Engineering, Isfahan University of Technology, Isfahan, Iran 2 Abstract: In this study, a composite made of nano zeolite and hydrogel with some biodegradable polymers (polyethylene glycol, poly acrylic acid and polyacrylamid) was prepared and its controlled drug release was tested in phosphate buffer solution (with pH =7.8) and at temperature of 37°C which is similar to the human blood situation. The drug release rate over time was measured with UV spectrophotometer. Various percentages of nano zeolite were used and their effects on the controlled drug release were considered. A sample containing 3 wt.% zeolite had lowest rate of drug release. Distribution of particles in the polymer matrixes was studied by scanning electron microscopy (SEM) and their characteristics were identified by X-ray diffraction. The temperature and pH effects on the controlled drug release from hydrogel nano zeolite were investigated. Key words: Controlled release Antibiotics Hydrogel Nano zeolite Tissue INTRODUCTION There are several researches on the drug release process since 1930 [1, 2]. For the first time, estrogen was compressed into a tablet, placed under the skin and its release was studied. The release of loaded hormones was studied in 1950 [3]. Figure 1 is according to the drug conventional usage. As shown in this figure, drug concentration firstly increases and then suddenly decreases in plasma [1] while a uniform drug concentration is observed for the controlled release. Fig. 1: Drug concentration in plasma for the drug It can also be demonstrated that the drug uniform conventional usage and for the drug controlled concentration is obtained drug patient recovery when the release (DDD) [1] drug delivery system is applied. Another benefit for patients is this they no need to remember that they should composite is prepared by combining the various take their drugs over time [4-7]. components with specific release profiles [14]. Antibiotics This paper aims to develop biodegradable polymer are directly loaded into the system and the controlled nano zeolite polymer composite systems for controlled release is applied over time. It maintains bone tissue from release drug delivery [8]. Care and maintenance of bone inflammation [15-17]. tissue or body after exposure is important. It is necessary The controlled drug release system in body to have good body cells to stick to it and influence its supplies medicine cycle without a serious harm to the growth [9-12]. For this purpose, the biodegradable liver. Further, lower amounts of drug will be required in polymeric hydrogel nano zeolite composite with the this method [18]. Since some medicines affect the special antibiotics release can be coated on bone to protect it locations of body, local drug delivery system is preferred [13]. The biodegradable polymeric hydrogel nano zeolite while medicine gulp will affect the whole of body [19].