_____________________________________________________________________________________________________ *Corresponding author: Email: adewunmi_rofiat@yahoo.com; Cite as: Adewunmi, Rofiat Funmilola, Abubakar Gidado, Hassan B. Yesufu, and Hassan Zanna. 2024. “Neutralizing Effect of Solanum Dasyphyllum Schumach. &Thonn Extract Against Naja Nigricollis Venom-Induced Toxicity”. International Journal of TROPICAL DISEASE & Health 45 (6):217-26. https://doi.org/10.9734/ijtdh/2024/v45i61553. International Journal of TROPICAL DISEASE & Health Volume 45, Issue 6, Page 217-226, 2024; Article no.IJTDH.116240 ISSN: 2278–1005, NLM ID: 101632866 Neutralizing Effect of Solanum dasyphyllum Schumach. &Thonn Extract against Naja nigricollis Venom- induced Toxicity Rofiat Funmilola Adewunmi a* , Abubakar Gidado b , Hassan B. Yesufu c and Hassan Zanna b a Department of Biochemistry, Al-Ansar University, Maiduguri, Borno State, Nigeria. b Department of Biochemistry, University of Maiduguri, Borno State, Nigeria. c Department of Pharmaceutical Chemistry, University of Maiduguri, Borno State, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: https://doi.org/10.9734/ijtdh/2024/v45i61553 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/116240 Received: 22/02/2024 Accepted: 26/04/2024 Published: 05/06/2024 ABSTRACT Background: Clinical treatments for snakebite envenomation typically involve the administration of antivenom, which can lead to various side effects. However, due to the limitations of conventional antivenoms in effectively treating snakebite envenomation, scientists are now exploring alternative sources for potential antivenom compounds, particularly those derived from plants. Solanum dasyphyllum belongs to the Solanaceae family. This plant has been found to possess several beneficial properties, including neuromuscular, anti-poisoning, and antispasmodic effects. Aim of the Study: This study aimed to investigate the phytochemical constituents and the In-vivo detoxifying effect of S. dasyphyllum extract against N. nigricollis-induced toxicity. Original Research Article