International Journal of Medical Dentistry 209 ON THE MODIFICATIONS OF THE LIPIDIC BIOCHEMICAL PARAMETERS AND EXTENT OF PERIODONTAL AFFECTION Abstract Scope of the study: evaluation of the extent of perio- dontalalteration, correlated with the plasmaticlevels of cholesterol and of the metabolization time of plasmatic lipides. Materials and method: The patients forming the expe- rimental group were recruited sequentially, along 6 months, among those having addressed the private dental office for routine examinations. The experimental group included 39 patients (20 women and 19 men, with ages between 50-60 years, mean age: 54.4±3.1) affected with periodontal diseases, while the control group – 40 patients (26 women and 14 men, with ages between 50-60 years, mean age: 54.4±2.8). There followed measurement of the ŕ jeun plasmatic lipids and of glucose concentrations in blood. Results and discussion: The values of plasmatictri- glycerides were higher in the patients of the experimental group, comparatively with the subjects of the control one (+39%), yet no difference has been registered for HDL cho- lesterol, while the mean plasmatic cholesterol levels and the LDL cholesterol levels in subjects suffering from peri- odontitis were significantly higher, with approximately 8 and 13%, comparatively with the control. The frequency of hypercholesterolemy in the first group of subjects was approximately double vs. the control. Conclusions: The pathological levels of triglycerides were about 6.5 times more frequent in periodontitis, com- paratively with those of the control group, yet no diffe- rentce was observed for the HDL cholesterol level. Keywords: periodontal disease, plasmatic triglycerides,hyp ercholesterolemia. INTRODUCTION At present, numerous studies suggest that the cardiovascular diseases may be associated with the infectious ones. The pathological modi- fications observed in vascular ischemic diseases were superposed on those caused, among others, by infections – the periodontal one, included.[1] The question whether the infection may pre- dispose to atherosclerosis is still unanswered, yet, undoubtedly, the viral and bacterial patho- genic agents are certainly responsible – either directly or indirectly – for the debut of athe- rosclerosis [2-4]. Hyperlipidemy and hyperglycemy represent major risk factors in cardiovascular diseases [5,6]. In recent years, several proofs, demonstra- ting the connection between the periodontal pathology and an increased risk of cardiovascu- laraffections have been provided [1,3,7]. Nowa- days, numerous researches associate the systemic maladies – thecoronarian diseases – with the higher values of the markers of systemic inflam- mation and of the hemostatic factors [4,8,9]. The high levels of the reactive blood C pro- tein, of leukocytes, fibrinogene and of other markers of inflammation, frequently associated with a subsequent risk of cardio-vascular dis- ease, evidenced that the high levels of the inflam- mation markers might contribute to the formation of the atheromatous plaque [9,10]. To elucidate such an association, the authors analyzed the standard blood variables known as risk markers for cardiovascular diseases, both in healthy patients and in those with periodontal problems [5,8,9,10,11]. Increased values might be mentioned in hypercholesterolemy, diabetes, hypothyroidism, billiary infections, cholestase, billiary obstruc- tion, nephrotic syndrome, diets rich in choles- terol, sedentary life, obesity, hereditary hypercholesterolemy, hyperlipoproteinemias [6,12,13]. ON THE MODIFICATIONS OF THE LIPIDIC BIOCHEMICAL PARAMETERS AND EXTENT OF PERIODONTAL AFFECTION Amelia Elena Surdu Macovei 1 , Liliana Pasarin 2 , Oana Potârnichie 2 , Adriana Balan 3 1. PhD student, Dept. of Periodontology, Faculty of Med. Dent. “Gr. T. Popa” U.M.Ph. Iaşi 2. Assist. Prof. PhD, Dept. of Periodontology, Faculty of Med Dent “Gr. T. Popa” U.M.Ph. Iaşi 3. Assoc. Prof. PhD, Dept. of Pedodontics and Orthodontics, Faculty of Med. Dent., “Gr. T. Popa” U.M.Ph. Iaşi Corresponding author: Balan Adriana – balan.gheo@yahoo.com Periodontology