457 Copyright © All rights are reserved by Jaime Portilla. Modern Approaches on Material Science Opinion Pyrazolo [1,5-A] Pyrimidines an Interesting Scaffold for Optical Applications Alexis Tigreros 1 and Jaime Portilla 2 * 1 Post doctoral Researcher, Departamento de Química, Universidad de Los Andes, Bogotá DC, Colombia 2 Associate Professor, Departamento de Química, Universidad de Los Andes, Bogotá DC, Colombia *Corresponding author: Jaime Portilla, Associated Professor, Bioorganic Compounds Research Group, Department of Chemistry, Universidad de los Andes, Carrera 1 No. 18A-10, Bogotá, Colombia Received: March 22, 2021 Published: April 01, 2021 ISSN: 2641-6921 DOI: 10.32474/MAMS.2021.04.000178 Opinion Organic fluorescent compounds are playing and will play an important role in scientific research in the next decades owing to their potential technological applications in the fields of chemo sensors, biological imaging, and optical devices [1]. With hundreds of metal-free dyes published every year an immediate question arises: is there any room for new organic fluorophores? To find an appropriate answer, we should analyze the present and past of organic fluorophores. On one hand, conventional organic fluorophores like pyrene, anthracene, or perylene are essentially non-fluorescent in the solid-state, which limits their usage in practical applications. On the other hand, more complex and modern organic dyes such as BODIPY, Rhodamine, or coumarin, to name a few, with exceptional optical properties both in solution and solid-state lack of good sustainable performance, with expensive manufacture processes and high amounts of wastes release during their production (Figure 1). Consequently, the answer to the above question is yes, as modern society we really need better fluorophores and thus, it is highly desirable to find modern alternatives that combine excellent photophysical performance with low-cost and efficient synthetic approaches. In this context, many reasons allow us to think that pyrazolo[1,5-a] pyrimidines, well-known for their wide applications in medicinal chemistry, emerge also as an important alternative for optical applications due to their proven synthetic versatility [1]. Figure 1: