Prevalence of Cardiac Dysfunction in MIS-C in Children (MIS-C) related to COVID-19 Amar Taksande * , Sachin Damke, Rewat Meshram, Sham Lohiya, Richa Chaudhary, Rupesh Rao Department of Paediatrics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi Meghe, Wardha, Maharashtra, India Corresponding author: Amar Taksande, Department of Paediatrics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi Meghe, Wardha, Maharashtra State, India, Tel: 9822369233; E- mail: amar.taksande@gmail.com Abstract Background: COVID-19 in children normally causes mild infectious illness, but serious repercussions can occur in combination with both acute infection and related phenomena in children, like the Multisystem Inflammatory Syndrome (MIS-C). In rural hospitals, there is less information available on Cardiac abnormality in MIS-C. Objectives: To know the prevalence of cardiac dysfunction of MIS-C children having COVID-19. Methodology: The MIS-C patients in this prospective research will be diagnosed using WHO criteria. On admission, MIS-C patients with cardiac marker positive will have an anomaly in one or more of the following: Electrocardiography, Brain Natriuretic Peptide (BNP), serum troponin, and/or echocardiogram. Results: We will determine the prevalence of cardiac dysfunction in MIS-C when the study is completed. We will compare outcome factors such as hospital stay days, ICU admission, and death based on the therapy received. We all also study the correlation between the inflammatory marker and LV dysfunction. Conclusion: The study will most likely provide information on the prevalence of heart abnormality in MIS-C children. Also, the outcome of the MIS-C with cardiac dysfunction will be revealed. Keywords Cardiac dysfunction; MIS-C; COVID-19; Children; Coronary dilatation Introduction In December 2019 in Wuhan, China a new strain of coronavirus found which is known as novel coronavirus which involves mainly respiratory tract system. According to genome analysis, they found that it is beta coronavirus and it is connected to SARS virus. While the majority of COVID-19 patients have mild to moderate sickness, nearly 14% have a severe condition that needs inpatient treatment and oxygen assistance, and 5% require admission to an intensive care unit.[1] Because of infection and septic shock, MODS, ARDS and cardiac damage COVID-19 may be exacerbated. [2] Children with COVID-19 typically have mild symptoms than adults, with cough and fever is most common, and co infection has been discovered. [3,4] Only a few cases of newborns with COVID-19 have been documented; those who did develop mild illnesses. [5] There is no major difference in COVID-19 symptoms in non- pregnant or pregnant and in adults. Droplet precautions help to prevent the spread of respiratory infections caused by large droplets. Wear a medical mask if you are operating within one meter of the patient. COVID-19 typically causes a milder pathogenic illness course in children, but serious complications can occur in interaction with both acute infection and related phenomena such as MIS-C. Adults have been developing neurological symptoms ranging from a simple headache to seizures, peripheral neuropathy, stroke, demyelinating diseases, and encephalopathy. Neurological problems show widely depending on age and underlying comorbidities, as do respiratory and cardiac signs of COVID-19. Cardiovascular abnormalities have been observed in people suffering from this condition, in addition to pulmonary complications and limitations associated with infection. Clinical outcomes have included myocardial infarction, valvular abnormalities, myocarditis, increased coagulopathies which cause peripheral vascular problems, and even left ventricular dysfunction which leads to heart failure. Heart cell damage caused by direct invasion by virus or by Review Article This is an open access article distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non‑commercially, as long as the author is credited and the new creations are licensed under the identical terms. How to cite this article: Taksande A*, Damke S, Meshram R, Lohiya S, Chaudhary R, Rao R. Prevalence of Cardiac Dysfunction in MIS-C in Children (MIS-C) related to COVID-19. Ann Med Health Sci Res. 2021;11:84-88 ©2021Annals of Medical and Health Sciences Research 84