Accepted Article This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/pai.12360 This article is protected by copyright. All rights reserved. Title Page Title Tacrolimus vs. cyclosporin eyedrops in severe cyclosporin resistant vernal keratoconjunctivitis: a randomized, comparative, double-blind, crossover study. Authors Neri Pucci,1 Roberto Caputo,2 Laura di Grande,1 Cinzia de Libero,2 Francesca Mori,1 Simona Barni,1 Lorena di Simone,3 Annamaria Calvani,3 Franca Rusconi,4 Elio Novembre,1 Affiliations 1Allergy Unit, A. Meyer Children's Hospital, Florence, Italy 2Ophthalmology Unit, A. Meyer Children's Hospital, Florence, Italy 3Pharmaceutical Service, A. Meyer Children's Hospital, Florence, Italy 4Epidemiology Unit, A. Meyer Children's Hospital, Florence, Italy Running Title Tacrolimus vs. cyclosporin eyedrops in severe vernal keratoconjunctivitis Corresponding Author Mori Francesca Allergy Unit, Anna Meyer Children’s Hospital, Department of Pediatrics, University of Florence Viale Pieraccini, 24 50139, Florence, Italy Phone: +390555662955 Mobile: +393476159711 FAX: +390555662400 E mail: f.mori@meyer.it; francymori@libero.it Material in the electronic repository (if applicable): Questionnaire for the assessment of quality of life Introduction Vernal keratoconjunctivitis (VKC) is a chronic and sight-threatening form of bilateral conjunctivitis typically characterized by the presence of giant “cobblestone” papillae in the upper palpebral conjunctiva (tarsal form) or at the limbus (bulbar form) (1). Corneal