DOI: 10.1126/science.1141448 , 916 (2008); 319 Science et al. William E. Balch, Adapting Proteostasis for Disease Intervention www.sciencemag.org (this information is current as of March 13, 2008 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/319/5865/916 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/319/5865/916#otherarticles , 18 of which can be accessed for free: cites 40 articles This article http://www.sciencemag.org/cgi/collection/cell_biol Cell Biology : subject collections This article appears in the following http://www.sciencemag.org/about/permissions.dtl in whole or in part can be found at: this article permission to reproduce of this article or about obtaining reprints Information about obtaining registered trademark of AAAS. is a Science 2008 by the American Association for the Advancement of Science; all rights reserved. The title Copyright American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. (print ISSN 0036-8075; online ISSN 1095-9203) is published weekly, except the last week in December, by the Science on March 13, 2008 www.sciencemag.org Downloaded from