1 Below is the unedited draft of the article that has been accepted for publication (© The International Journal of Psychiatry in Medicine, 2019, V. 54(1), P. 53-63. DOI: https://doi.org/10.1177/0091217418791438) Brain Space and Time in Mental Disorders: Paradigm Shift in Biological Psychiatry Andrew A. Fingelkurts a* , Alexander A. Fingelkurts a a BM-Science – Brain and Mind Technologies Research Centre, FI-02601, Espoo, Finland E-mail: andrew.fingelkurts@bm-science.com Abstract: Contemporary psychiatry faces serious challenges because it has failed to incorporate accumulated knowledge from basic neuroscience, neurophilosophy and brain-mind relation studies. As a consequence, it has limited explanatory power, and effective treatment options are hard to come by. A new conceptual framework for understanding mental health based on underlying neurobiological spatial-temporal mechanisms of mental disorders (already gained by the experimental studies) is beginning to emerge. Keywords: EEG; brain; mental disorders; nested hierarchy; metastable balance; neuronal assemblies; functional connectivity; DSM-5