Taro (Colocasia Esculenta (L.) Schott) Extract didn’t Increase Superoxide Dismutase (SOD) but Decrease C- Reactive Protein (CRP) in Male Wistar Rat (Rattus Norvegicus) Diabetes Mellitus Model Demak Vera Rachelia a , Gde Ngurah Indraguna Pinatih a,b , Ni Nyoman Ayu Dewi a,c * *ayu.dewi@unud.ac.id 1 Biomedical Masters Study Program, Faculty of Medicine, Udayana University Denpasar, Bali, 80114, Indonesia. 2 Department of Clinical Nutritional, Faculty of Medicine, Udayana University Denpasar, Bali, 80114, Indonesia. 3 Department of Biochemistry, Faculty of Medicine, Udayana University Denpasar, Bali, 80114, Indonesia. Abstract Backgrounds: In hyperglycemia induced by streptozotocin, free radicals and oxidative stress conditions occur. This also reduced SOD enzymes while increasing CRP. This study aimed to analyze effect of flavonoid-rich taro leaves ethanol extract on SOD levels and serum CRP levels in rats diabetes melitus model induced by streptozotocin. Methods: Experimental study with a pretest-posttest control group design 26 healthy rats were randomly divided into 2 groups. The control group was given 2 ml aquadest and treatment group was given 400mg/kgBW ethanol extract of taro leaves in 2 ml aquadest. Before and after treatment, blood serum was collected for SOD and CRP analysis using the ELISA technique. Results: SOD level in control goup before and after given plasebo were reduce insignificantly (from 5.37±0.69 ng/ml to 5.26±1.50 ng/ml ;p = 0.830). Furthermore, CRP level in control group before and after given plasebo were not signifcantly different (from 3.39±0.24 ng/ml to 3.56 ±0.43 ng/ml ; p = 0.308). SOD level in treatment group before and after given taro extract were increase but not significant (from 5.33 ±1.14 ng/ml to 6.20 ±2.64 ng/mL; p = 0.239). However, CRP level in control group after given plasebo decrease significantly (from 3.56 ± 0.43 ng/mL to 2.93 ± 0.47 nmol/mL ; p = 0.009).Conclusion: ethanol extract of taro leaves did not increase SOD levels but decrease CRP levels in rats model diabetes melitus induced by streptozotocin. Further studies are needed to confirm extract of taro leaves as external antioxidant. Keywords: CRP, Diabetes mellitus, SOD, Streptozotocin, Taro leaves 1. Introduction Diabetes melitus is a chronic hyperglycemic condition that causes autoimmune, metabolic and hereditary problems (Egan and Dinneen, 2019). Insulin action and pancreatic beta cell disfunction are two factors that induce diabetes mellitus. The breakdown of the function between insulin action and insulin production, resulting in hyperglycemia, is the initial factor that causes diabetes mellitus. The existence of pancreatic beta cell dysfunction is the second factor (Noormohammadi et al., 2022). When insulin production is diminished, the body is unable to perform its physiological duty of maintaining glucose levels. Insulin resistance causes a rise in glucose in the liver as well as a reduction in glucose absorption in the muscle, liver, and adipose tissue. If this pattern persists, diabetes mellitus develops (Galicia-Garcia et al., 2020). Hyperglycemia induces the development of reactive oxygen species on pancreatic cells in diabetes mellitus. In the body, an imbalance of reactive oxygen species with antioxidants causes oxidative stress, insulin resistance, decreased insulin secretion, DNA, RNA, protein, and lipid damage, endothelial damage in both large and small blood vessels, increased expression of proinflammatory cytokines, growth factors, 739 www.ijrp.org IJRP 2022, 105(1), 739-747; doi:.10.47119/IJRP1001051720223640