composition by bioelectrical impedancemetry analysis) and respira- tory status (forced vital capacity). Statistical analysis was done by using Mann-Whitney test, Chi² tests, Cox model and multivariate logistic regression. Results: Two hundred and eighty-five patients were included. Among the 63.9% for whom gastrostomy was indicated, 63.7% had accepted the placement. The median delays diagnosis-indication and indica- tion-placement were 7.3 months [3.2–15.0] and 2.7 months [0.9–5.8], respectively. At diagnosis, bulbar onset, a loss of one point of body mass index and of bulbar functional scale were positively associated with indication of gastrostomy (aOR = 10.0; p = 0.002, aOR = 1.17; p = 0.025 and aOR = 1.19; p = 0.002, respectively). Weight loss > 5% significantly increased the risk of death by 17% (p < 0.0001). However, gastrostomy placement did not have impact on the survival (aHR = 1.25; p = 0.22). Conclusions: Neurological and nutritional criteria were associated with an indication of gastrostomy. The gastrostomy placement had no impact on survival. The study of an earlier placement of gastrostomy and on the impact of the level of enteral nutrition associated might be of interest in further prospective studies. Disclosure of Interest: None declared. MON-PO450 BODY COMPOSITION OF PATIENTS WITH PULMONARY TUBERCULOSIS (TB), ATTENDING DISTRICT CHEST CLINICS (DCC) OF COLOMBO AND GAMPAHA DISTRICTS. R. Jayatissa 1 , N. Wijenayaka 2 , N. de Alwis 1 , A. Perera 1 , P. Karunaratna 3* , A. Munasinghe 2 , V. Fernando 1 . 1 Nutrition Department, Medical Research Institute, Colombo, 2 Medical Nutrition Unit, Colombo North Teaching Hospital, Ragama, 3 Medical Nutrition Unit, National Hospital, Colombo, Sri Lanka * Corresponding author. Rationale: TB on its own is associated with wasting, loss of weight and fat free mass (FFM) and this may be a major contributing factor to increased mortality in these individuals. Published data on body composition analysis of pulmonary TB is very limited worldwide including Sri Lanka To investigate the usefulness of body composition of pulmonary TB patients for specific treatment. Methods: A cross sectional study was carried out including 195 pulmonary TB patients attending DCC, in central and one regional clinic. All new recruits in these clinics were enrolled for the study during 3 months period. Anthropometry and body composition analysis was done. Results: Therewere 77.9% males and 22.1% females, with mean age of 49.6 ± 13.9 and 42.6 ± 18.7 years respectively. 41.4% males and 48.8% females were underweight (<18.5 of BMI). Males were having 20.0% and 5.1% of total fat mass and visceral fat mass respectively, whereas females were having 21.6% and 5.0%. Males had skeletal muscle mass of 23.9 ± 4.2 kg and females had 24.3 ± 3.6 kg. Underweight males had 12% and 83.2% of fat mass and muscle mass respectively whereas females had 17% and 80.9%. Underweight males had visceral fat level of 2% and females had 1.5%. Conclusions: Half of pulmonary TB patients were underweight. Females were having low total fat mass and males were within normal limits. Fat mass is affected than muscle mass in underweight patients. Disclosure of Interest: None declared. MON-PO451 INTERACTION BETWEEN MAGNESIUM INTAKE-ASSOCIATED CARDIAC BENEFITS AND POTASSIUM INTAKE IN CHRONIC HEART FAILURE R. Herrera Saucedo 1* , J.B. Ivey Miranda 1 , E. Almeida Gutiérrez 1 , G. Saturno Chiu 1 , G.H. Mendoza Zavala 1 , A. Chávez Mendoza 1 , M.J. Olalde Román 1 , M.C. Revilla Monsalve 1 , G. Borrayo Sanchez 1 , D. González Islas 2 , L. Verdeja Vendrell 2 . 1 UMAE Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, 2 Heart Failure and Respiratory Distress Clinic, Instituto Nacional de Enfermedades Respiratorias ‘Ismael Cosío Villegas’, Mexico City, Mexico * Corresponding author. Rationale: Magnesium serves as a cofactor in more than 300 enzymatic reactions and plays a key role in the body’s anti-oxidative mechanisms. High magnesium intake has been associated with better prognosis in patients with heart failure (1). However, this beneficial effect is quite variable, suggesting other factors may interact with the positive effect of high magnesium intake (2). Therefore, we sought to determine if potassium intake (an important ion in cardiac function) could interact with the beneficial effects of magnesium in patients with heart failure (HF). Methods: Patients were prospectively enrolled in this cross-sectional study. We included patients with stable chronic HFand reduced left ventricularejection fraction (LVEF). The evaluation of dietary magne- sium and potassium intake was obtained through a food processor nutrition analysis software. NT-proBNP (main biomarker in heart failure hence higher levels imply poor prognosis) was measured to assess severity of HF. Dietary evaluation and NT-proBNP measure- ments were done the same day. Multivariable linear regression and partial correlations were used to assess association between magne- sium and NT-proBNP. Results: We included 60 patients (age 60 ± 14 years, male 78%). Only 31% of participants consumed the recommended magnesium daily intake. In the whole population, magnesium intake showed a modest correlation with NT-proBNP (rho −0.30, p = 0.020). However, after comprehensive multivariable regression, a strong interaction was noted between potassium and magnesium intake. The beneficial effect of magnesium intake on NT-proBNP occurred only in patients with low potassium intake ( partial correlation −0.57, p = 0.002), whereas magnesium intake was not correlated with NT-proBNP when potassium intake was high ( partial correlation 0.02, p = 0.938; p interaction = 0.048). Conclusions: In patients with stable chronic heart failure and reduced LVEF, high magnesium intake was associated with beneficial cardiac effects only when potassium intake was low. Higher potassium intake led to no cardiac benefits with high magnesium intake. References 1. Nielsen F. H. (2016). Guidance for the determination of status indicators and dietary requirements for magnesium. Magnesium Research, 29(4), 154–160. 2. Wannamethee S. G., Papacosta O., Lennon L., & Whincup P. H. (2018). Serum magnesium and risk of incident heart failure in older men: The British Regional Heart Study. European Journal of Epidemiology, 33(9), 873–882. Disclosure of Interest: None declared. S225 Abstracts / Clinical Nutrition 38 (2019) S59–S296