Development of siRNA-loaded chitosan nanoparticles targeting Galectin-1 for the treatment of glioblastoma multiforme via intranasal administration Matthias Van Woensel, Nathalie Wauthoz, R´ emi Rosi` ere, V´ eronique Mathieu, Robert Kiss, Florence Lefranc, Brecht Steelant, Ellen Dilissen, Stefaan W. Van Gool, Thomas Mathivet, Holger Gerhardt, Karim Amighi, Steven De Vleeschouwer PII: S0168-3659(16)30095-5 DOI: doi: 10.1016/j.jconrel.2016.02.032 Reference: COREL 8145 To appear in: Journal of Controlled Release Received date: 13 November 2015 Revised date: 18 February 2016 Accepted date: 18 February 2016 Please cite this article as: Matthias Van Woensel, Nathalie Wauthoz, R´emi Rosi`ere, V´eronique Mathieu, Robert Kiss, Florence Lefranc, Brecht Steelant, Ellen Dilissen, Ste- faan W. Van Gool, Thomas Mathivet, Holger Gerhardt, Karim Amighi, Steven De Vleeschouwer, Development of siRNA-loaded chitosan nanoparticles targeting Galectin- 1 for the treatment of glioblastoma multiforme via intranasal administration, Journal of Controlled Release (2016), doi: 10.1016/j.jconrel.2016.02.032 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.