1 (Revised Electronic Supplementary Information for Chemical Communications) Hyaluronic acid-methotrexate conjugate for targeted therapy of rheumatoid arthritis Jung Min Shin, a ‡ Seol-Hee Kim, bc ‡ Thavasyappan Thambi, a Dong Gil You, a Jueun Jeon, a Jong Oh Lee d , Bong Youl Chung d , Dong-Gyu Jo, be* and Jae Hyung Park ae* a School of Chemical Engineering, College of Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea b School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea c Center of Bioanalysis, Korea Research Istitute of Standards and Science, Daejeon 305-340, Republic of Korea d Humedix, Co., Ltd., Megavalley 401, Haguiro, Dongangu, Anyang 431-767, Republic of Korea e Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Suwon 440-746, Republic of Korea ‡These authors contributed equally to this paper *Corresponding authors: Jae Hyung Park, Ph.D. Tel: +82-31-290-7288; fax: +82-31-299-6857; e-mail: jhpark1@skku.edu Dong-Gyu Jo, Ph.D. Tel: +82-31-290-7776; fax: +82-31-292-8800; e-mail: jodg@skku.edu Electronic Supplementary Material (ESI) for ChemComm. This journal is © The Royal Society of Chemistry 2014