International Journal of Advances in Medicine | July 2021 | Vol 8 | Issue 7 Page 897 International Journal of Advances in Medicine Rai S et al. Int J Adv Med. 2021 Jul;8(7):897-901 http://www.ijmedicine.com pISSN 2349-3925 | eISSN 2349-3933 Original Research Article Clinical and microbiological profile of diabetic foot ulcers in a tertiary care setup: a cross sectional analysis Siddharth Rai 1 *, Harleen Uppal 2 , Arvind Kumar Sharma 3 , Anil Kumar Gupta 4 INTRODUCTION India is the diabetic capital of the world, the diabetic population in the country is close to hitting the alarming mark of 69.9 million by 2025 and 80 million by 2030. 1 In diabetic population, the lifetime risk of a diabetic foot ulcer (DFU) is 15% and around 28% of them may require some form of amputation. 2 Chronic diabetes causes macro and microangiopathy and peripheral sensory and motor neuropathy. These neuropathies lead to foot deformities, in turn escalates to ischemia, and foot infection. 3 DFUs are responsible for considerable morbidity and a significant cost of health‐care worldwide. 4 Foot infections account for 20% of hospitalization of diabetic patients yearly. 5 Presence of superimposed infection in an already existing DFU, not only delays healing but also poses risk of systemic infection, ABSTRACT Background: Diabetes associated neuropathy and vasculopathy leads to development of diabetic foot ulcers (DFU). They are responsible for considerable morbidity and a significant cost of health‐care worldwide. The magnitude of the problem becomes worse in regions where foot care is inadequate like in our country. The aim of the study to determine the microbiological profile and antimicrobial susceptibility pattern of organisms isolated from patients with diabetic foot ulcers. Methods: The study was a cross sectional study done at King George’s Medical College, Lucknow from 2012-2014 in Lucknow, Uttar Pradesh. Based on the inclusion criteria sample were collected from 112 patients. The standard protocol for the identification of microorganisms was followed. A descriptive analysis of the data was done. Results: Out of the 112 ulcers total 180 isolates were found. Of the 112 cases, 78 were monomicrobial, 32 were polymicrobial, and 2 cases were sterile on culture. The most common bacteria found was Staphylococcus aureus. Most of the staphylococcus isolated were sensitive to vancomycin, teicoplanin, cephalosporins, linezolid levofloxacin and pipercillin-tazobactum. Nearly 65% of S. aureus were methicillin‐resistant S. aureus. Conclusions: This study compiled clinical and microbiological profile of diabetic foot ulcers along with their antibiotic susceptibility patterns. Our study illuminates light on a high figure of neglected and poorly treated NHUs which could have been managed well and early treatment will prevent devastating consequences such as sepsis and amputation. Keywords: Diabetic foot ulcer, Diabetes mellitus, Non-healing ulcer, Diabetic foot 1 Department of Physical Medicine and Rehabilitation, Apex Trauma Centre, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India 2 Department of Physical Medicine and Rehabilitation, Dr. Baba Saheb Ambedkar Medical College and Hospital, New Delhi, India 3 Department of Physical Medicine and Rehabilitation, AIIMS, Raebareli, India 4 Department of Physical Medicine and Rehabilitation, King George’s Medical University, Lucknow, India Received: 02 June 2021 Accepted: 18 June 2021 *Correspondence: Dr. Siddharth Rai, E-mail: siddharth.bmc@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: https://dx.doi.org/10.18203/2349-3933.ijam20212345