International Journal of Sciences: Basic and Applied Research (IJSBAR) ISSN 2307-4531 (Print & Online) http://gssrr.org/index.php?journal=JournalOfBasicAndApplied --------------------------------------------------------------------------------------------------------------------------- 118 The Aqueous and Methanol Extracts of Ficus asperifolia (Moraceae) Improve Reproductive Hormones Profile in High Fat Diet-Induced Obese Rats Esther Ngadjui a *, Georges Romeo Bonsou Fozin b , Aime Cesaire Momo Tetsatsi c , Modeste Wankeu-Nya d , Patrick Brice Defo Deeh e , Alango Pepin Nkeng-Efouet f , Telesphore Benoit Nguelefack g , Pierre Watcho h a,b,c,e,g,h Animal Physiology and Phytopharmacology Laboratory, University of Dschang, Box 67 Dschang, Cameroon d Laboratory of Animal Biology and Physiology, Department of Animal Organisms Biology, University of Douala, Box 24157, Douala-Cameroun f Department of Chemistry, Faculty of Science, University of Dschang, P.O. BOX 67 Dschang-Cameroon. a Email: estherngadjui@yahoo.fr, b Email: bonsougeorges@yahoo.com, c Email: aimecesairemomo@yahoo.fr, d Email: modewans@yahoo.com, e Email: deehdefo@yahoo.fr, f Email: alangop@yahoo.fr, g Email: nguelefack@yahoo.fr, h Email: pwatcho@yahoo.fr Abstract Ficus asperifolia (Moraceae), is a plant used as fertility booster. We investigated the effects of F. asperifolia extracts on sex hormones profile in high-fat diet (HFD)-induced estrus cycle disturbances in rats. Female Wistar rats were fed either with HFD (n=161) or standard diet (n=8) for 10 weeks. After this period, 70 obese rats with abnormal estrus cycle were distributed into 14 groups of 5 animals each and treated for one and four weeks with distilled water (10 mg kg-1), Tween-80 (5%-10 mg kg-1), lutenyl (0.88 μg kg-1) and aqueous or methanol extract (100 or 500 mg kg-1) of F. asperifolia. At the end of each period, plasmatic estradiol and progesterone levels were determined. Acute toxicity parameters were also evaluated. HFD impaired reproductive hormones profile and estrous cycle after 10 weeks of treatment. ------------------------------------------------------------------------ * Corresponding author.