Accepted Manuscript FARS2 deficiency; new cases, review of clinical, biochemical, and molecular spectra, and variants interpretation based on structural, functional, and evolutionary significance Mohammed Almannai, Julia Wang, Hongzheng Dai, Ayman W. El-Hattab, Eissa A. Faqeih, Mohammed A. Saleh, Ali Al Asmari, Ali H. AlWadei, Yaser I. Aljadhai, Amal AlHashem, Brahim M. Tabarki, Matthew A. Lines, Dorothy K. Grange, Ruba Benini, Abdulaziz S. Alsaman, Adel Mahmoud, Panagiotis Katsonis, Oliver Lichtarge, Lee-Jun C. Wong PII: S1096-7192(18)30377-9 DOI: doi:10.1016/j.ymgme.2018.07.014 Reference: YMGME 6386 To appear in: Molecular Genetics and Metabolism Received date: 22 June 2018 Revised date: 25 July 2018 Accepted date: 25 July 2018 Please cite this article as: Mohammed Almannai, Julia Wang, Hongzheng Dai, Ayman W. El-Hattab, Eissa A. Faqeih, Mohammed A. Saleh, Ali Al Asmari, Ali H. AlWadei, Yaser I. Aljadhai, Amal AlHashem, Brahim M. Tabarki, Matthew A. Lines, Dorothy K. Grange, Ruba Benini, Abdulaziz S. Alsaman, Adel Mahmoud, Panagiotis Katsonis, Oliver Lichtarge, Lee-Jun C. Wong , FARS2 deficiency; new cases, review of clinical, biochemical, and molecular spectra, and variants interpretation based on structural, functional, and evolutionary significance. Ymgme (2018), doi:10.1016/ j.ymgme.2018.07.014 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.