www.ejpmr.com │ Vol 10, Issue 9, 2023. │ ISO 9001:2015 Certified Journal │ Alburyhi et al. European Journal of Pharmaceutical and Medical Research 32 RECENT INNOVATIONS OF DELIVERY SYSTEMS FOR ANTIMICROBIAL SUSCEPTIBILITY STUDY OF CIPROFLOXACIN BIODEGRADABLE FORMULATIONS FOR POST OPERATIVE INFECTION PROPHYLAXIS Mahmoud Mahyoob Alburyhi* 1 , Abdalwali Ahmed Saif 1 , Maged Alwan Noman 1 and Randa Mohammed Saif 2 1 Professor of Pharmaceutics and Industrial Pharmacy, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Sana'a University, Sana'a, Yemen. 2 B.SC, Department of Pharmaceutics, Faculty of Pharmacy, Aden University, Aden, Yemen. Article Received on 02/07/2023 Article Revised on 22/07/2023 Article Accepted on 12/08/2023 INTRODUCTION Formulation of a new dosage form is one of the most challenging aspects in pharmaceutics for its importance in designing and developing a new dosage form. Postoperative infection (POI) is one of the numerous global health issues that must be prevented by adhering to a number of strategies and procedures; otherwise, it may result in a significant and, in some cases, fatal issue. The primary cause of POI is gram-negative bacteria, and because of the nature of these bacteria, the widespread use of antibiotics, some poor social behaviors, and other factors, the bacteria develop antibiotic resistance, which may result in failure to protect against these types of infection and cause a string of infections and health issues that can result in patient loss of a body part or, in severe cases, mortality. [1-3] The Centers for Disease Control and Prevention (CDC) describe surgical site infections (SSIs) as an infection that happens within 30 days of an operation or within a year in the case of material implantation. [3] These infections can also be divided into superficial infections (skin and subcutaneous tissues surrounding the incision) and deep infections (the fascia, muscle, bone, or implant). The most frequent SSI-causing pathogen is Staphylococcus Aureus (S. Aureus), which is similar to the skin's natural flora. [4] Under normal situations, healthy soft tissue and bone are very resistant to infection. But following the tissue trauma inherent in surgical treatments, the affected tissue's resistance to infection significantly declines. Devitalized tissue that is more prone to infection might result from the disruption of the blood flow during surgery and the following impairment of the microcirculation afterward. These devitalized tissues provide the best culture medium for bacterial growth when joined with the equipment and the nearby hematoma. [5] SSI, which affects up to one-third of surgical patients, was the most often reported and observed healthcare- associated infection in low- and middle-income nations. Although SSIs are far less common in high-income nations, they are nevertheless the second most common type of infection related with healthcare in Europe and the USA. [1,6,7] SJIF Impact Factor 6.222 Research Article ISSN 2394-3211 EJPMR EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH www.ejpmr.com ejpmr, 2023, 10(9), 32-36 ABSTRACT Staphylococcus Aureus is a pathogen that frequently causes postoperative infections. Systemic injection of antibiotics is an intrinsically poor method for achieving high local tissue drug concentrations because the circulatory system equally distributes medications throughout the entire body. In the present study was to determine how well the biodegradable, lipid-based antibiotic Ciprofloxacin tablet formulations combat the primary cause of postoperative infection. The molding technique was employed to produce recent innovation delivery system formulation tablets for Ciprofloxacin. The microbiological studies were carried out in a laminar flow condition, and Muller Hinton agar was used as a medium to replicate body tissue. Zones of inhibition for all Ciprofloxacin formulations were lower than those attained using standards. At p 0.05, every Ciprofloxacin formulation deviates significantly from the reference. Based on findings, the result was deemed satisfactory because it was within the acceptable quality control standards for antibiotics. In conclusion Staphylococcus Aureus is regarded susceptible to antimicrobial developed Ciprofloxacin formulations, so they could be used in the prevention of post-operative infection (POI). KEYWORDS: Ciprofloxacin, Delivery systems, Recent innovations, Formulations, Biodegradable lipid base tablets, Zone of Inhibition, Staphylococcus Aureus, Antimicrobial susceptibility. *Corresponding Author: Prof. Mahmoud Mahyoob Alburyhi Professor of Pharmaceutics and Industrial Pharmacy, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Sana'a University, Sana'a, Yemen.