1986 DOI: 10.18535/ijmsci/v3i7.4 International Journal Of Medical Science And Clinical Inventions Volume 3 issue 7 2016 page no. 1986-1991 e-ISSN: 2348-991X p-ISSN: 2454-9576 Available Online At: http://valleyinternational.net/index.php/our-jou/ijmsci Tumor Marker for Diagnosis and Monitoring Response to chemotherapy for Oesophagus Cancer Patients Ranjit S. Ambad 1 , Suryakant Nagtilak 2 , Shivkumar Chandraker 3 , Dr Madhukar R. Jape 4 1 Ph.D Scholar Dept. of Biochemistry Subharti Medical College Meerut. 2 Professor. Dept. of Biochemistry Subharti Medical College Meerut (UP) 3 Professor Dept. of Pathology CCM Medical College Durg. 4 Principal Rama Medical College Hospital & Research center Hapur. Address for Correspondences: Ranjit Sidram Ambad Assistant Professor Dept. of Biochemistry, Chandulal Chandrakar Memorial Medical College Durg, (CG)490024 Keywords: - CEA, ELISA, Cisplastin, capecitabine esophagus cancer, chemotherapy Introduction Oesophagus cancer, cardia cancer and gastric cancer are three of the most commonly seen malignant tumor of gastrointestinal cancer. Oesophagus cancer is start in the inner layer and grows outward. Since two types of cell can line the oesophagus; there are two main types of oesophagus cancer. 1. Squamous cells carcinoma 2. Adenocarcinomas Squamous cell carcinoma is normally linked with squamous cells. Cancer starting in these cells is called squamous cell carcinoma. This type of cancer can occur anywhere along the oesophagus. ABSTRACT Purpose: - To analyze the level of serum Carcinoembryonic antigen (CEA) before and after Different Cycle Of chemotherapy in oesophagus cancer patients. Methods: - For the study total 120 cases of carcinoma of esophagus of stage I, stage II stage III and Stage IV (before and after different cycle of chemotherapy) were selected. All patients were clinically and histological diagnosed. 42 age and sex matched healthy normal subjects selected as control. CEA activity was measured in the in the serum of control group (n=42) and in patients with esophagus cancer (n=120). Results: - Mean CEA activity in serum was significantly higher in oesophagus cancer patients as compared to control (p<0.001). After chemotherapy (stage II) the activity of CEA was significantly higher than before chemotherapy (stage I). In stage II (after first cycle of chemotherapy) activity was significantly decreased than stage III (before chemotherapy) and the activity of CEA was significantly decreased in stage IV (after third cycle of chemotherapy) than stage III (after second cycle of chemotherapy). Conclusion:- Based on the data from our study, it can be stated that serum CEA measurement in plasma may be useful tumor marker in esophageal cancer, its activity might helpful to predict the response of chemotherapy in advance stage of cancer. An initial increased level of CEA before and first cycle of chemotherapy may not indicate tumor progression, but may be represent a transient tumor marker surge phenomenon after second and third cycle of chemotherapy in patients responding to treatment.. Statistically significant change in tumor marker CEA level during the process of treatment in esophageal cancer patients, with a positive response and no established disease progression during study period, near about 12 months after the treatment, point to CEA as an important predictive factor.