Open Peer Review on Qeios [Case Study] Photobiomodulation (PBMT) and Its Interface with Sleep Dentistry: Clinical Case Report Vitor Hugo Panhoca 1 , Carolina Alvarez 2 , Viviane Brocca de Souza 2 , Simone Aparecida Ferreira 2 , Marcela Sene-Fiorese 2 , Vanderlei Salvador Bagnato 3 1 Universidade de São Paulo 2 Universidade de São Paulo (USP) 3 Texas A&M University - College Station Funding: This study was supported by the Embrapii, CEPOF-USP (FAPESP) and the Santa Casa de Misericordia de São Carlos. The authors acknowledge the financial support from the Financier of Studies and Projects (FINEP; grant no. 01.13.0430-00), São Paulo Research Foundation (FAPESP; grant nos. 2013/14001-9 and 2013/07276-1; CEPOF—CEPID Program). Potential competing interests: No potential competing interests to declare. Abstract Introduction: This study aimed to evaluate and raise the therapeutic hypothesis of the use Photobiomodulation (PBMT) as a complementary therapy in patients with sleep disorder (SD) in a broad approach involving other pathologies superimposed on this pathology. Methods: This is a clinical case report of a patient with Parkinson's disease (PD) complaining of sleep disorder. The proposed treatment is the use of photobiomodulation (PBMT) with intraoral application using an innovative dosimetry. SD was assessed using an adapted analogue scale. Results: In the evaluation performed after the last session, there was an improvement in the sleep disorder compared to the pre-treatment evaluation. However, one month after the end of the treatment, it was observed that the quality of sleep remained practically the same. Conclusion: The results of the present study suggest that photobiomodulation could become a new therapeutic perspective for the treatment of sleep disorders (SD). However, controlled, and randomized clinical studies must be carried out to strengthen and confirm the evidence observed in this case report. Vitor Hugo Panhóca 1,2 , Carolina Alvarez 1,3 , Viviane Brocca de Souza 1,3 , Simone Aparecida Ferreira 1,3 , Marcela Sene-Fiorese 1,* , and Vanderlei Salvador Bagnato 4 1 Institute of Physics of São Carlos, University of São Paulo (USP), São Paulo, Brazil. 2 Department of Biotechnology, Federal University of São Carlos, São Carlos, São Paulo, Brazil. 3 Central Paulista University Center — UNICEP, São Carlos, Brazil. 4 Texas A&M University, Texas, United States of America. * Corresponding author: Marcela Sene-Fiorese, Institute of Physics of São Carlos, University of São Paulo (USP), São Paulo 13568-695, Brazil. Email: m_sene2004@yahoo.com.br Qeios, CC-BY 4.0 · Article, May 13, 2024 Qeios ID: S6F5JD.3 · https://doi.org/10.32388/S6F5JD.3 1/9