_____________________________________________________________________________________________________ *Corresponding author: E-mail: osahon.abu@uniben.edu; Asian Journal of Research in Biochemistry 4(1): 1-11, 2019; Article no.AJRB.47534 Extract of Icacina trichanta Improves lipid Profile and CCl4- Induced Histological Changes in Wistar Rats O. D. Abu 1* , B. M. Aleogho 1 and F. O. Omoregie 1 1 Department of Biochemistry, Faculty of Life Sciences, University of Benin, P.M.B. 1154, Benin City, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. Author ODA designed the study, performed the statistical analysis, wrote the protocol and first draft of the manuscript. Authors BMA and FOO managed the literature searches and analyses of the study. All authors read and approved the final manuscript. Article Information Editor(s): (1) Dr. Fabio Altieri, Professor, Department of Biochemical Sciences, Faculty of Pharmacy and Medicine, Sapienza University, Rome, Italy. Reviewers: (1) Aldilane Gonçalves Da Fonseca, Universidade Federal do Rio Grande do Norte, Brazil. (2) Muhammad Shahzad Aslam, Xiamen University, China. (3) S. Murugesan, Pachaiyappa’s College, University of Madras, India. Complete Peer review History: http://www.sdiarticle3.com/review-history/47534 Received 15 November 2018 Accepted 13 February 2019 Published 07 March 2019 ABSTRACT Aim: This study was undertaken to investigate the effect of aqueous leaf extract of Icacina trichanta on lipid profile and CCl 4 - induced histological changes in Wistar rats. Study Design: Liver damage was induced with CCl 4 and the rats were treated with aqueous extract of Icacina trichanta. Place and Duration of Study: This study was undertaken at the Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City, Nigeria, between January to March 2014. Methodology: Phytochemical screening, lipid profile analysis and histopathological studies were carried out. Thirty-five male rats were divided into seven groups of five rats each. Groups I (normal control) and III rats were not induced. Groups II (negative control), IV, V, VI and VII were induced with 1.0 ml CCl 4 /kg body weight. Group II rats were not administered the extract, while those in Original Research Article