DOI: 10.32668/jitek.v10ii.1078 This is an open-access article under the CC-BY-SA License JURNAL ILMU DAN TEKNOLOGI KESEHATAN Vol 10, No 2, Maret 2023 ISSN: 2338-9095 (Print) ISSN: 2338-9109 (online) Relationship Between Results of Genexpert RT-PCR and Erythrocyte Sedimentation Rate in Suspected Tuberculosis Patients Tanti Listiyowati 1,2 , Dita Pratiwi Kusuma Wardani 2* , Tantri Analisawati Sudarsono 2 , Linda Wijayanti 3 1 BKPM Purwokerto, Indonesia 2 Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Purwokerto, Indonesia 3 RSUD Banyumas, Indonesia *Email : dita.tiwhie@gmail.com Article history Send, Des 19 th , 2023 Reviewed, Mar 27 th , 2023 Received, Mar 31 th , 2023 ABSTRACT Pulmonary tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB). The GeneXpert MTB/RIF is a diagnostic tool that can automatically detect the presence of MTB by molecular examination and can be used to detect MTB resistance to rifampicin. Erythrocyte Sedimentation Rate (ESR) was used to determine the rate at which erythrocytes settle in the blood. The ESR rate is related to inflammation caused by infection. This study aimed to determine the relationship between GeneXpert MTB/RIF results and ESR in suspected tuberculosis patients. This research uses a cross-sectional study. The sample used in this study were 56 new suspected TB patients who had never been treated for Anti-Tuberculosis Drugs (ATD) and underwent GeneXpert MTB/RIF examination. The sample was collected by purposive sampling with two result groups: Rif Sen and negative. The Chi-Square test (X 2 ) results show p- value = 0.000 and OR = 0.032. There is a significant relationship between GeneXpert MTB/RIF examination and ESR values in suspected tuberculosis. Keywords: GeneXpert; Erythrocyte Sedimentation Rate; Rif Sen; Tuberculosis ABSTRAK Tuberkulosis (TB) paru merupakan penyakit infeksi yang disebabkan oleh bakteri Mycobacterium tuberculosis (MTB) dan menyerang organ paru-paru. Pemeriksaan GeneXpert MTB/RIF merupakan perkembangan alat diagnostik yang dapat mendeteksi adanya MTB secara otomatis dengan pemeriksaan molekuler dan dapat digunakan untuk mendeteksi resistensi MTB terhadap rifampisin. Laju Endap Darah (LED) merupakan pemeriksaan yang digunakan untuk menentukan kecepatan eritrosit yang mengendap dalam darah. Kecepatan laju endap darah berhubungan dengan inflamasi yang disebabkan adanya infeksi. Tujuan penelitian ini untuk mengetahui hubungan hasil GeneXpert MTB/RIF dengan LED pada suspek penderita Tuberkulosis. Penelitian ini menggunakan cross-sectional study. Sampel yang digunakan dalam