187 11 Nutraceuticals as Modulators of Gut Microbiota Role in Therapy! Rupali Joshi Panse Contents 11.1 Introduction ......................................................................................... 188 11.2 Digestion, Agni, and Their Symbiotic Association with Gut Microbiome........................................................................................... 189 11.3 Gut Health through the Lens of Ayurveda ......................................... 189 11.4 “Vishishte Paka Vipaka” (Sus/40/10 Dalhan Tika).............................. 191 11.5 Concept of Ama with Respect to Dysbiosis ........................................ 192 11.6 Virudhha (Incompatible Food): A Common Causative Factor for Gut Dysbiosis and Inflammatory Disorders........................................ 193 11.7 Prakriti (Body Constitution): Personalized Spectrum of Human Microbiome........................................................................................... 194 11.8 Stress and Mental Health and Ayurveda Psychobiotics...................... 195 11.9 Dincharya, Rutucharya, and Biorhythm of Gut Microbiome ............. 195 11.10 Loopholes of Conventional Probiotics................................................. 197 11.11 Concept of Ayurvedic Nutraceuticals for Gut Health ......................... 198 11.12 Ayurvedic Pharmacologic Notions for Modulation of Gut Mucosa (see Figure 11.2) ................................................................................... 198 11.12.1 Deepana: Pharmacological Expression of Nutraceuticals for Enhancing Gut Microbiome Activity................................ 198 11.12.2 Pachana: Pharmacological Expression of Nutraceuticals to Enhance Nutrient Absorption through Effective Digestion ................................................................................200 11.12.3 Anulomana: Therapeutic Rejuvenation of the Colon Microbiome ............................................................................ 201 11.13 Prebiotic Activity of Single or Polyherbal Ayurvedic Herbs............... 201 11.14 Ayurvedic Nutraceuticals and Their Role in Gut Modulation ............ 202 11.15 Efficacy of Traditional and Ayurvedic Functional Food in Gut Health ...................................................................................................206 11.15.1 Curd Treated with Herbs .......................................................206 DOI: 10.1201/9781003333821-11 TNF_11_K60126_C011_docbook_new_indd.indd 187 TNF_11_K60126_C011_docbook_new_indd.indd 187 6/16/2023 7:44:51 PM 6/16/2023 7:44:51 PM