led us to use 10 mcg of intracavernous injection of alprostadil before and after treatment with LISWT for such purpose. Material and Method: 10 patients with vasculogenic ED and average age of 58 years old; four patients with moderate ED and six patients with severe ED; All patients received 10 mcg of alprostadil intracavernous injections (ICI) before the first session of LISWT and 1 month after the last treatment (fig1.A.B.C). Patients received six (if partial response to ICI:Erection Hardness Score (EHS) 3) or four (if good response to ICI:EHS¼4) weekly sessions of LISWT (PiezoWave2 from Richard WOLF) depending of the response to ICI , with an energy flux density of 0.16mj/mm2 and frequency set to 8 Hz, wave focus penetration depth set to 10mm. Patient received 6000shocks/session, 2000 shocks on the perineum (1000 each crus penis), 2000 shocks on dorsum penis, 2000 shocks on lateral aspect of penis (1000 each side). Results: Three patients had good response to10mcg of ICI alprostadil and received four weekly sessions of LISWT; seven patients had partial response to 10 mcg of ICI alprostadil and received six weekly sessions of LISWT; after 1 month of treat- ment the three patients who had good response initially to10 mcg ICI had the same response to 8mcg of ICI ; while four patients of the seven who had partial initial response to 10mcg ICI had good response to 10mcg ICI after the treatment (57% improvement) (Table1.) . No patient had any complication from ICI. Conclusion: ICI might be a good method to evaluate objectively the response to LISWT and to predict the number of LISWT sessions needed for ED. Randomized studies which include EHS, IIEF, and dose of the ICI are needed to evaluate if this method is feasible and applicable. Disclosure: Work supported by industry: no. 288 THE ROLE OF LOW-INTENSITY SHOCK WAVE THERAPY ON ERECTILE DYSFUNCTION Simoes de Oliveira, P. 1 ; Ribeiro de Oliveira, T. 1 ; Martins, F. 1 ; Lopes, T. 1 1 SCI Centro de Urologia, Portugal Objective: To evaluate the role of low-intensity shock wave therapy (LiSWT) on erectile dysfunction (ED). Materials & Methods: We prospectively analyzed all patients who underwent LiSWT, from June 2016 to October 2017. Erectile function was assessed before and 6 weeks and 3 months after treatment with the International Index of Erectile Function (IIEF-5) and with penile doppler duplex ultrasound. Results: 20 patients were enrolled. Median age was 62.5 years (27-73). Twelve patients (60%) had arteriogenic ED, four pa- tients (20%) arteriogenic and venous leak ED, three patients (15%) post-radical prostatectomy ED and one patient (5%) venous leak ED. Median IIEF-5 score before LiSWT was 13.5 (Q1¼10; Q3¼15), median IIEF-5 at 6 weeks after LiSWT was 15.5 (Q1¼11; Q3¼20.5) (p 0.00), at 3 months was 16.5 (Q1¼9.5; Q3¼21.8) (p 0.05) with 14 (70%) and 8 patients (66.7%) presenting IIEF-5 improvement at 6 weeks and 3 months respectively. Median peak systolic velocity (PSV) pre- LiSWT was 27.7 cm/s (Q1¼20.4; Q3¼29.6), post-LiSWT 39.3 cm/s (Q1¼24.3; Q3¼48.1) (p 0.06) with 8 patients (66.7%) presenting improvement after LiSWT. Patients with arteriogenic DE presented the most siginificant improvement (91.7%) at 6 weeks after LiSWT (p 0.01). Conclusion: LiSWT is a non-invasive therapy that has the po- tential to cure ED, presenting good functional outcomes specially in arteriogenic ED. Disclosure: Work supported by industry: no. 290 EFFICACY OF LOW-INTENSITY SHOCK WAVE THERAPY FOR THE TREATMENT OF ED IN DIABETIC PATIENTS : A POOLED ANALYSIS Spivak, L. 1 ; Vinarov, A. 1 ; Shultz-More, T. 2 ; Appel, B. 3 ; Gruenwald, I. 3 1 Sechenov University, Russia; 2 Medispec Urology, Israel; 3 Rambam Healthcare Campus, Israel Objectives: Low-intensity shock wave therapy (LIeESWT) has been shown to be effective as a non-invasive treatment for men suffering from vasculogenic erectile dysfunction (ED). Diabetes induced ED is more severe and more difficult to treat due to combined vasculopathy and peripheral neuropathy that both negatively affect the erectile mechanism. Our aim Before LISWT 1 month after LISWT Patients with Good response to 10 mcg ICI of alprostadil 3 4 Patients with Partial response to 10 mcg ICI of alprostadil 7 3 Patients with Good response to 8mcg ICI of alprostadil 0 3 J Sex Med 2018;15:S123eS407 Proceedings of the 21st World Meeting on Sexual Medicine S239