1587 Journal of Chemical Health Risks www.jchr.org JCHR (2024) 14(3), 1587-1598 | ISSN:2251-6727 Integrating Zebrafish Research into Pharmaceutical Studies Aishwarya Deshmukh 1 , Arpita Umap 1 , Divyanshu Gahane 1 , Shyam Rnagari 1* , Krishna Gupta 1 , Milind Umekar 1 1 Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur-441002 (Received: 04 February 2024 Revised: 11 March 2024 Accepted: 08 April 2024) KEYWORDS Zebra fish, disease features, clinical trials.medicinal therapies, screening. etiology ABSTRACT: Zebrafish are the source of several medicinal therapies that have lately made their way into clinical trials or the clinic. Because of their highly conserved molecular pathways, clinically relevant etiology, and disease features, zebrafish have become a potent preclinical model for human illness. They are also widely known for their contributions to developmental biology. When combined with cell-specific or tissue-specific reporters and gene editing technologies, zebrafish respond to small molecules and drug treatments at physiologically relevant dose ranges. This allows for the study of drug activity at single-cell resolution within the complex body of an animal, across tissues, and over an extended period. These characteristics allow for the discovery of new drug classes as well as the repurposing of existing medications for individualized and compassionate usage. They also enable high-throughput and high-content phenotypic drug screening. Drugs and drug leads that are investigated in zebrafish frequently have an inter-organ mechanism of action and would not be found by methods of focused screening. Here, we go over the significance of zebrafish as a model for drug discovery, the methods by which these findings are made, and upcoming changes to fully utilize zebrafish's potential for medical research. Introduction Zebrafish are the source of several medicinal therapies that have lately made their way into clinical trials or the clinic. Because of their highly conserved molecular pathways, clinically relevant etiology, and disease features, zebrafish have become a potent preclinical model for human illness. They are also widely known for their contributions to developmental biology. Zebrafish react to medications and small compounds at physiologically relevant dosage ranges. In this Review, we go over recent developments in zebrafish disease modeling that have demonstrated the organism's potential for drug discovery and in vivo drug mechanism exploration, as well as its usefulness as a whole-animal model for preclinical drug repurposing and personalized medicine. Zebrafish have been a popular model organism for whole-animal chemical genomics and drug development because of their capacity for in vivo screening and the phenotypic' applicability to human disorders [1]. Aim and Objective The aim is to Review zebrafish as a preclinical model In the sector of pharmacy for studying drug screening and also the effect of diseases and drugs. The objective to carry out the combined form of review of all the research done on zebrafish are: 1. To get aware of the use of drugs in human as well as fisheries medicinal science. 2. To establish the idea of using fish as a preclinical model for drug screening as compared to the other rodent animals used. 3. To familiarize with the established and broad importance of the pharmaceutical field in veterinary and fisheries science. 4. To study the health of fish by use of drugs in uncontrolled and test concentrations. 5. To know the interrelation between fish health and human health. 6. To get in touch with aquatic biodiversity and conservation of its ecosystem in medical or pharmaceutical ways.