Journal Pre-proof Prevalence of comorbid substance use in major depressive disorder in community and clinical settings, 1990-2019: Systematic review and meta-analysis Glenn E. Hunt , Gin S. Malhi , Harry Man Xiong Lai , Michelle Cleary PII: S0165-0327(19)32742-9 DOI: https://doi.org/10.1016/j.jad.2020.01.141 Reference: JAD 11590 To appear in: Journal of Affective Disorders Received date: 8 October 2019 Revised date: 9 December 2019 Accepted date: 25 January 2020 Please cite this article as: Glenn E. Hunt , Gin S. Malhi , Harry Man Xiong Lai , Michelle Cleary , Prevalence of comorbid substance use in major depressive disorder in community and clinical set- tings, 1990-2019: Systematic review and meta-analysis, Journal of Affective Disorders (2020), doi: https://doi.org/10.1016/j.jad.2020.01.141 This is a PDF ﬁle of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the deﬁnitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its ﬁnal form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2020 Published by Elsevier B.V.