International Journal of Research Publication and Reviews, Vol 3, no 11, pp 3125-3130, November 2022 International Journal of Research Publication and Reviews Journal homepage: www.ijrpr.com ISSN 2582-7421 Formulation and Evaluation of Effervescent Granul from African Leaf Extract (Vernonia amygdalina Del.) Yeni Novita Sari* 1 , Maria Dona Octavia 1 , Intan Putri Utamii 1 , Muthia Fadhila 1 Department of Pharmaceutics, School of Pharmaceutical Science Padang (STIFARM Padang), West Sumatera, Indonesia, 25147 DOI: https://doi.org/10.55248/gengpi.2022.3.11.44 A B S T R A C T African leaf plants (Vernonia amygdalina Del.) contain many secondary metabolites, one of which is flavonoids. African leaves are commonly used in traditional medicine. This study aims to determine the extract of African leaf plants can be formulated in the preparation of effervescent granules and is suitable for the criteria for good granules. African leaves were macerated using 96% ethanol as solvent and evaporated to obtain a thick extract. Then, the African leaf extract obtained was formulated into effervescent granules with a concentration of 10%. The production of effervescent granules is based on the principle of the wet granulation method. The results showed that the evaluation of the effervescent granules of African leaf extract was only suitable for the requirements of the haussner factor, porosity, particle size distribution, moisture content, angle of repose, dispersion, and pH but did not suitable for the requirements of compressibility and flowability. The flavonoid content in the African leaf extract is 96,2276% while the effervescent granule is 94,634%.94,634%. Keywords: African leaf, Vernonia amygdalina Del., Effervescent Granules Introduction Indonesia is a country with a very abundant flora, people can use plants as a traditional medicine to minimize unwanted side effects. Traditional medicine that has been used for generations by ancestors aims to save time and cost, improve health, will be safe when consumed appropriately, and have side effects that can be estimated (Supardi & Susyanty, 2010). As many as 3.4 billion of the world's population including Indonesia are very dependent on traditional medicine because 88% of the population uses drugs made from natural ingredients for the continuation of their primary health (Sarker & Lutfun, 2007). Figure 1. Vernonia amygdalina plant (Yeap et al., 2010) One of the plants used as a folk remedy is the African leaf plant (Vernonia amygdalina Del). African leaf or also known as bitter leaf (Fatimah & Sundu, 2020), is a plant that contains nutrients and chemical compounds that are used in traditional medicine and can be used for various diseases, such as cancer drugs, heart disease treatment, lowering cholesterol, preventing stroke, regulating blood sugar, lowering fever, malaria, hepatitis, coughing,