A CROSS SECTIONAL STUDY ON THE THYROID PROFILE OF NEONATES BORN TO HYPOTHYROID MOTHERS IN A TERTIARY CARE CENTRE IN CHENNAI P. GUNASUNDARI a1 , MURALIDHARAN SATHYAMOORTHY b , CHRISTINA MARY P. PAUL c , KALAVATHY VICTOR d , I. PREETHI EVANGELINE e , A. KIRAN f AND S. KARAN KUMAR g abcdefg Department of Pediatrics, ACS Medical College & Hospital (Dr. M.G.R. Educational and Research Institute), Velappanchavadi, Chennai, Tamilnadu, India ABSTRACT Retrospective study was done to estimate the prevalence of congenital hypothyroidism (CH) among new born babies born to hypothyroid mothers on thyroxine in ACS Medical College & Hospital. Datas were collected from the case sheets in medical record department. The prevalence of CH was 1 in 2500 live births with no gender difference. KEYWORDS: Congenital Neonatal Hypthyroidism, New Borns, Hypothyroidism in Antenatal Mothers, No Gender Difference Congenital hypothyroidism (CH) occurs approximately 1:2000 to 1:4000 new borns. The clinical manifestations are often subtle and not present at birth. This is likely to due to the tranplacental passages of some maternal thyroid hormones while many infants have some thyroid production of there own. CH is one of the most common preventable cause of mental retardation. Among thyroid hormones if free T4 level is low and TSH level is elevated a diagnosis of CH is confirmed. The prevalence of CH generally has no relationship with maternal hypothyroidism state & treatment with thyroxine in antenatal mothers. New borns can have devastating neuro developmental consequences if not detected and treated promptly. Screening procedures for CH have developed in many countries & it has virtually eradicated intellectual disability due to severe CH. Screening has resulted in increased detection of mild CH. The underlying cause reminds obscure in many cases. Thyroid hormone is essential for normal growth & neurological development particularly in first few years of life. Hypothyroidism during this period may damage the growth & development. MATERIALS AND METHODS From new borns blood is taken by prick method for screening. Blood is collected between 2-5 days preferably after 72 hours . Estimation is done by ELISA method. New borns with abnormal results are reviewed and venepuncture blood sample are drawn for confirmation. Free T4, TSH results are compared to age normal reference ranges & treatment should be started as early as possible . The present study was conducted in the department of paediatrics & in neonatal intensive care unit. ACS Medical College & Hospital from January 2016 to September 2019. It was a retrospective study of congenital hypothyroidism Proforma was used to record information on age, sex, birth weight, mode of delivery, antenatal mother on thyroxine (regular/irregular) treatment. Investigations like free T3, T4, TSH levels were estimated . Inclusion Criteria New borns between 2-5 days born to hypothyroid mothers were included. Exclusion Criteria New borns below 48 hours & above 5 days were excluded. Table 1: Background Variables of The Study Subjects Variable Classification of Variable Number (out of 80) % Mode of birth Vaginal 8 10 C- section 72 90 Gender Male 39 48.8 Female 41 51.2 Birth weight < 3 kgs 61 76.3 ≥ 3 kgs 19 23.7 Table 2: Thyroid profile of the study subjects Parameter Mean Standard Deviation, Standard Error 95% C. I T-3 1.09 0.53, 0.06 0.97 – 1.21 T-4 7.75 3.47, 0.39 6.99 – 8.51 TSH 3.79 3.53, 0.39 3.03 – 4.52 DOI: 10.32606/IJSR.V10.I2.00001 Received: 18-05-2019 Accepted: 19-10-2019 Indian J.Sci.Res. 10 (2): 81-83, 2020 Original Research Article ISSN: 0976-2876 (Print) ISSN: 2250-0138 (Online) _________________________________________ 1 Corresponding author