~ 6 ~ International Journal of Pharmacognosy and Life Science 2021; 2(2): 06-10 E-ISSN: 2707-2835 P-ISSN: 2707-2827 www.pharmacognosyjournal.com IJPLS 2021; 2(2): 06-10 Received: 05-05-2021 Accepted: 08-06-2021 Sadiqul Alam Department of Pharmacy, Tripura University, A Central University, Suryamaninagar, Agartala, Tripura, India Abu Saleh Nizam Uddin Siddik Department of Pharmacy, Tripura University, A Central University, Suryamaninagar, Agartala, Tripura, India Ranadeep Borgohain Girjananda Chowdhury Institute of Pharmaceutical Science, Azara, Kmamrup, Assam, India Priyakshi Chutia Girjananda Chowdhury Institute of Pharmaceutical Science, Azara, Kmamrup, Assam, India Corresponding Author: Sadiqul Alam Department of Pharmacy, Tripura University, A Central University, Suryamaninagar, Agartala, Tripura, India Biological and pharmacological properties of Clerodendrum colebrookianum Walp: A review Sadiqul Alam, Abu Saleh Nizam Uddin Siddik, Ranadeep Borgohain and Priyakshi Chutia DOI: https://doi.org/10.33545/27072827.2021.v2.i2a.33 Abstract Clerodendrum colebrookianum Walp is a seasonal perennial shrub which is native to South and Southeast Asia. Different species within the Clerodendrum genus possess tremendous pharmacological and medicinal properties. These emanate from the presence of many unique bioactive secondary metabolites traditionally; it is used in the treatment of various diseases due to its immense therapeutic potential. In view of extensive ethno-medicinal importance and utilization in various forms of ethnomedicinal uses of Clerodendrum colebrookianum in the north eastern region, the present paper is an effort to compile the existing information on folklore medicine uses by different communities of north eastern India. It is extensively used by the indigenous people of Northeast India as a remedy for treatment of various diseases like high blood pressure, diabetes, stomachache, jaundice, cough, rheumatism, dysentery and various skin diseases. The plant possesses different pharmacologically active components like Colebrin A, Colebrin B, Colebrin D, Colebrin E, β-Sitosterol etc. This review reported various pharmacological activities of the plant such as antidiabetic, antihypertensive, anti- inflammatory, analgesic, hepatoprotective, antioxidant, anthelmintic and some other activities which provide scientific evidence for some traditional therapeutic claims. Keywords: Clerodendrum colebrookianum, ethnomedicinal, pharmacological, antihypertensive, therapeutic Introduction Since ancient time, in search for the remedy for the various ailments, people always looked for potential drugs in medicinal plants and over the generations the plant-derived products have been a vital part of our traditional health care system. The uses of plant-derived products provide a large source of natural drug for treatments of several metabolic disorders and infectious diseases. World Health Organization (WHO) estimated that 80% of the developing and under developing countries population depends on plant derived medicines which have its own advantages like i.e. low or no adverse effects, poses minimum environmental hazards, easily available and affordable [1-3] . However, infectious diseases remain as world's major problem, accounting for 33% deaths each year and threatening to affect many more millions of people. The undesirable side effects along with the unprecedented upsurge in antibiotic resistance among pathogens upon synthetic drugs exposure have necessitated for looking at alternative therapeutics, particularly the plant based one [4-6] . Parasitic infections are known to lead for the release of free radicals which have severe consequences on functioning of cellular metabolism. Overproduction of ROS (reactive oxygen species) either by normal oxygen metabolic process or by infections, apart from playing a beneficial role, may leads to oxidative stress thereby causing damage to vital components of the cell [7] . Generally, free radicals have been implicated in several disorders (diabetes mellitus, heart diseases, cancer, acquired immunodeficiency syndrome, arthritis, liver disorder, ageing, etc.), and the treatment by antioxidants has gained an utmost importance in the treatment [8] . The presence of both antioxidant and antibacterial compounds in a single medicinal plant extracts, will have the dual therapeutic potential, thus helping in fighting infectious diseases and its further consequences. Although, plants used in the traditional medicine have been identified and their applications well-documented for many, however, the biological efficacy of many plants is yet to be scientifically verified [9-11] .