April 2024 255 Volume 23 • Issue 4 Copyright © 2024 ORIGINAL ARTICLE Journal of Drugs in Dermatology SPECIAL TOPIC Effectiveness and Safety of a New Hyaluronic Acid Injectable for Augmentation and Correction of Chin Retrusion Andreas Nikolis MD PhD, a,b Shannon Humphrey MD, c Jason K. Rivers MD, d,e Vince Bertucci MD, f Nowell Solish MD, g,h William McGillivray MD, i Kristy Bailey MD, j Nathan Rosen MD, k Andrei Metelitsa MD, l,m Annika Rugheimer MSc, n Felipe Weinberg MD, o Inna Prygova MD, n Torun Bromée PhD n aVictoria Park Medispas, Montreal, Quebec, Canada BDivision of plastic surgery, McGill University, Montreal, Quebec, Canada c The Centre for Clinical Trials Inc.,Vancouver, British Columbia, Canada d Pacific Derm,Vancouver, British Columbia, Canada; e Department of Dermatology and Skin Science, the University of British Columbia, Vancouver, British Columbia, Canada; f Bertucci MedSpa, Woodbridge, Ontario, Canada g Sweat Clinics of Canada, Toronto, Ontario, Canada; h University of Toronto, Toronto, Ontario, Canada i Dr. William McGillivray Inc.,Vancouver, British Columbia, Canada; j FCP Dermatology, Toronto, Ontario, Canada k Dermetics, Burlington, Ontario, Canada; l Beacon Dermatology, Calgary, Alberta, Canada m Division of Dermatology, University of Calgary, Calgary, Alberta, Canada; n Galderma, Uppsala, Sweden; o Galderma, Dallas, TX Background: A hyaluronic acid (HA) filler intended for non-surgical improvement of chin appearance should ideally be of high strength/ firmness (high G') to allow for deep injections on the bone. HA SHA (Restylane ® Shaype ™ ) is a new hyaluronic acid (HA) injectable with high G' and high HA concentration (25 mg/mL), engineered by the new NASHA-HD ™ (High Definition) technology. HASHA is suitable to be placed periosteally, aiming to mimic the natural shape of the bony chin. This pivotal clinical investigation evaluated effectiveness and safety of HA SHA for augmentation and correction of chin retrusion. Methods: Subjects ≥18 years with mild or moderate chin retrusion by the Galderma Chin Retrusion Scale (GCRS), were randomized 3:1 to HA SHA (n=103) or no treatment (n=37). Assessments included GCRS (blinded evaluator), aesthetic improvement (Global Aesthetic Improvement Scale [GAIS]), subject satisfaction, and safety. Results: GCRS responder rate (≥ 1-grade improvement from baseline) was significantly higher for HA SHA (83.3%) vs controls (10.8%) at month 3 (P<0.001), and maintained through month 12 (P<0.001). Aesthetic improvement was high throughout the study in the HA SHA group, according to investigators (≥97%) and subjects (≥89%). Overall, subject satisfaction was high at month 3 and maintained at month 12. Product- or injection-related adverse events were mostly mild or moderate and transient. No product- or injection-related serious adverse events were reported. Conclusions: HA SHA , a new NASHA-HD ™ injectable with extra strength/firmness, was safe and effective for chin augmentation and correction of chin retrusion, with high aesthetic improvement and subject satisfaction throughout 12 months. J Drugs Dermatol. 2024;23(4):255-261. doi:10.36849/JDD.8145 ABSTRACT INTRODUCTION T he shape, projection, and profile of the chin are important components of facial attractiveness in both men and women. Chin retrusion may be perceived as less attractive and associated with a desire for chin correction or elongation.1 Procedures for enhancing chin appearance include surgical procedures, such as permanent alloplast implants (eg, silicone) bony osteotomy, autologous fat transplant, and non-surgical alternatives, such as different types of dermal fillers (eg, silicone, calcium hydroxylapatite, and hyaluronic acid (HA) fillers). 2-4 For patients seeking a minimally invasive and reversible option, HA fillers have shown high patient satisfaction and low risk of severe complications. 5 In addition to a favorable safety profile, filler treatments offer fast recovery 3, 6 , and the flexibility to tailor treatments to meet individual needs, including changes in appearance due to aging. Even though the global market offers a wide variety of HA fillers with different physicochemical and rheological characteristics, there remains a need for a strong/firm HA injectable that mimics the natural shape of the bony chin. NASHA ® technology utilizes minimal modification and mild processing that preserves the long natural HA chains, resulting in strong/firm products with high G’ (an indicator of strength/ doi:10.36849/JDD.8145 To order reprints or e-prints of JDD articles please contact sales@jddonline.com This document contains proprietary information, images and marks of Journal of Drugs in Dermatology (JDD). No reproduction or use of any portion of the contents of these materials may be made without the express written consent of JDD. If you feel you have obtained this copy illegally, please contact JDD immediately at support@jddonline.com JO10424