PAPER Uptake of genetic counseling among adult children of BRCA1/2 mutation carriers in France Fatima Belén Gauna Cristaldo 1,2 | Rajae Touzani 2,3 | Thémis Apostolidis 1 | Emmanuelle Mouret‐Fourme 4 | Dominique Stoppa‐Lyonnet 4,5,6 | Christine Lasset 7,8,9 | Jean‐Pierre Fricker 10 | Pascaline Berthet 11 | Claire Julian‐Reynier 2,3 | Julien Mancini 12 | Catherine Noguès 2,13 | Anne‐Déborah Bouhnik 2 1 LPS EA 849, Aix‐Marseille Université, Aix‐en‐Provence, France 2 Aix‐Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France 3 UMR1252, Institut Paoli‐Calmettes, Marseille, France 4 Department of Genetics, Institut Curie, Paris, France 5 INSERM U830, Institut Curie, Paris, France 6 Université Paris Descartes, Sorbonne Paris Cité, Paris, France 7 Département de Santé Publique, Centre Léon Bérard, Lyon, France 8 CNRS UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Lyon, France 9 Université Claude Bernard Lyon 1, Lyon, France 10 Service d'Oncogénétique, prévention, dépistage, CLCC Paul Strauss, Strasboug, France 11 Service d'oncologie génétique, Centre François Baclesse, Caen, France 12 Aix Marseille Univ, APHM, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, HopTimone, BioSTIC, Biostatistique et Technologies de l'Information et de la Communication, Marseille, France 13 Département d'Anticipation et de Suivi des Cancers, Oncogénétique clinique, Institut Paoli‐Calmettes, Marseille, France Correspondence Anne‐Déborah Bouhnik, Aix‐Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France. Email: anne‐deborah.bouhnik@inserm.fr Funding information INCA‐DGOS‐Inserm, Grant/Award Number: 6038; French National Institute of Cancer (INCa), Grant/Award Number: RPT08011AAA Abstract Objective: Genetic counseling in at‐risk families is known to improve cancer pre- vention. Our study aimed to determine the rate of uptake of genetic counseling among adult children of BRCA1/2 mutation carriers and to identify the potential psy- chosocial factors associated with uptake of genetic counseling. Methods: A self‐reported questionnaire was mailed to 328 BRCA1/2 mutation car- riers 10 years after BRCA1/2 test disclosure. Of the 233 carriers who returned the questionnaire (response rate = 71%), 135 reported having children over age 18 years and were therefore included in the analysis. Generalized estimating equations models were used to identify the factors associated with uptake of genetic counseling among adult children of mutation carriers. Results: Data were gathered for a total of 296 children (46% male, 54% female). The vast majority were informed about the familial mutation (90.9%) and 113 (38%; 95% CI, 32%‐44%) underwent genetic counseling. This percentage exceeded 80% in women over 40 years. In the multivariate model, female sex, advanced age, muta- tion in the father, diagnosis of cancer in the mutation‐carrying parent after genetic testing, and good family relationships were all factors associated with higher uptake of genetic counseling. Received: 22 March 2019 Revised: 5 June 2019 Accepted: 1 July 2019 DOI: 10.1002/pon.5169 Psycho‐Oncology. 2019;1–7. © 2019 John Wiley & Sons, Ltd. wileyonlinelibrary.com/journal/pon 1