CONFLICT OF INTEREST: None declared.
Koji KAMIYA,
1,2
Eiichi NISHIO,
1
Ai HORIO,
1
Yoshiki TOKURA
2
1
Department of Dermatology, Toyokawa City Hospital, Toyokawa, and
2
Department of Dermatology, Hamamatsu University School of Medicine,
Hamamatsu, Japan
doi: 10.1111/1346-8138.13187
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75(4): 439–443.
Blistering disease associated with diffuse large B-cell
lymphoma but without autoantibodies
Dear Editor,
Paraneoplastic pemphigus (PNP), usually associated with
hematological malignancy, is characterized clinically by severe
mucocutaneous and pulmonary involvement and histopatho-
logically by acantholysis and lichenoid tissue reaction.
1
PNP is
frequently associated with autoantibodies against desmoglein
(Dsg)3, envoplakin and periplakin.
1,2
We report a 68-year-old woman who presented with
atypical PNP with oral erosions and cutaneous pustules, and
(a)
(d) (e)
(b) (c)
Figure 1. Clinical appearance, histopatho-
logical findings and patch testing results.
Erythematous macules and coalesced
targetoid lesions on (a) the trunk, (b)
extending to the face and (c) the proximal
lower extremities. (d) Histopathology,
showing interface dermatitis (hematoxylin–
eosin, original magnification 9400; scale
bar, 50 lm). (e) Patch tests, showing a
positive reaction to amoxicillin.
Correspondence: Sakuhei Fujiwara, M.D., Ph.D., Department of Dermatology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-
machi, Yufu, Oita 879-5593, Japan. Email: fujiwara@oita-u.ac.jp
341 © 2015 Japanese Dermatological Association
Letters to the Editor