NATIONAL JOURNAL OF MEDICAL RESEARCH print ISSN: 2249 4995│eISSN: 2277 8810 Volume 2│Issue 4│Oct – Dec 2012 Page 484 ORIGINAL ARTICLE THE UTILITY OF BISPECTRAL INDEX FOR TITRATION OF PROPOFOL DOSAGES AND RECOVERY FROM ANAESTHESIA Heena Parikh 1 , Malini Mehta 2 1 Associate Professor, Department of Anesthesiology, GCS Medical College, Ahmedabad; 2 Professor and Head, Department of Anesthesiology, Waghodia, Baroda Correspondence: Dr. Heena Parikh, Email: drmrshc@gmail.com ABSTRACT Background: The use of clinical signs may not be reliable to measure the hypnotic component of anaesthesia. Bispectral Index monitoring provides a direct measurement of the hypnotic effect of the anaesthetic agent used and it may have certain clinical advantages over clinical signs. Objective: This study consists of dose requirement of propofol with bispectral Index monitoring and without bispectral Index monitoring. Material and Methods: In the present study, 100 patients were randomly divided into two groups (50 in each group), one group received Standard dose of propofol while the other received propofol infusion with BIS monitoring. Results: Mean amount of propofol for induction used was 1.6 vs 2.24 mg/kg in bispectral index group and standard group respectively. The inference was that the induction dose of propofol by Bispectral index and by standard practice was statistically highly significant with P<0.001. Similarly mean amount of propofol for maintenance used was 5.70 vs 8.88 mg/kg/hr in bispectral index group and standard group respectively. The inference was that the maintenance dose of propofol by Bispectral index and by standard practice was statistically highly significant with P<0.001. Conclusion: Dose requirement of propofol was less and early recovery from anesthesia with bispectral Index monitoring. Keywords: Bispectral Index monitoring system, propofol, anaesthetic drug consumption, awareness, recovery. INTRODUCTION BIS monitors are noninvasive devices that reflect a signal processed EEG 1 . Since the introduction of bispectral index in 1992, it has steadily gained clinical acceptance as a reliable measure to monitor the effects of anesthesia and sedation on the brain. 2, 3 A BIS monitor provides a continuous display of the current BIS and several parameters important to BIS monitoring. The BIS value is displayed in the upper left corner of the monitor. This score ranges from 0 to 100 and is a measure of cerebral electrical activity (Figure1) 4 . A BIS value between 40 and 60 indicates an appropriate level for general anesthesia. When the patient is awake, the cerebral cortex is very active and the EEG reflects vigorous activity. The pattern of activities changes when the patient is asleep or under general anesthesia (Figure 2) 5 . Under sedation can increase patient anxiety, agitation and the possible risk that the patient will be aware of and able to recall the surgery or procedure 6 . Over sedation can adversely affect patient’s vital signs and impair the ability to breathe. It can also increase the risk of complications, prolong the time of hospital stay and raise the cost of care. 1 Fig 1: BIS Index range guideline