Galley Proof 9/02/2018; 10:51 File: bmr–1-bmr169657.tex; BOKCTP/xjm p. 1 Journal of Back and Musculoskeletal Rehabilitation -1 (2018) 1–7 1 DOI 10.3233/BMR-169657 IOS Press Relationship of work disability between the disease activity, depression and quality of life in patients with ankylosing spondylitis Sinem Sa ˘ g * , Kemal Nas, Mustafa Serdar Sa˘ g, ˙ Ibrahim Tekeo˘ glu and Ayhan Kamanlı Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Sakarya University Medical Faculty, Sakarya, Turkey Abstract. OBJECTIVES: In this study, our objective was to determine the work productivity and work disability of the patients with ankylosing spondylitis (AS) and to investigate the relation of these parameters with disease activity, anxiety, depression and quality of life. PATIENTS AND METHODS: Fifty patients with the diagnosis of AS and 30 healthy control were included in the study. In patients with AS, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) was used to evaluate the disease activity; Bath Ankylosing Spondylitis Metrology Index (BASMI) was used to evaluate the spinal mobility and Bath Ankylosing Spondylitis Functional Index (BASFI) was used to determine the functional status. In addition, the Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire and The Short Form (SF-36) Health Survey was used to evaluate the health status, Hospital Anxiety and Depression Scale (HADS) was used for the evaluation of depression and anxiety and Work Productivity and Activity Impairment Questionnaire: Specific Health Problem v2.0 (WPAI:SHP) was used to evaluate the work productivity. RESULTS: In AS patients duration of disease at the diagnosis was 7.24 ± 6.23 years. The time lost at work due to the disease, decrease in the work productivity and impairment in the time off daily activities were worse in the patient group compared with the control group (p< 0.05). The impairment in the work productivity was correlated with BASDAI and depression; difficulty in time-off activities was correlated with BASFI and anxiety and depression was correlated with BASDAI (p< 0.05). While the impairment in work productivity was correlated with the subparameter vitality in SF-36, difficulty in time off activities was correlated with general health status, social functions, vitality and mental health (p< 0.05). CONCLUSION: In this study, we determined that AS had a significant influence on the working conditions and the factors related to the disease had a significant correlation with work productivity. Factors related to the psychology and the disease were also correlated with the working conditions. Keywords: Ankylosing spondylitis, work disability, quality of life 1. Introduction 1 Ankylosing spondylitis (AS), which affects the spine 2 and the sacroiliac joints, is a systemic, chronic and in- 3 flammatory rheumatic disease with an unknown etiol- 4 * Corresponding author: Sinem Sa˘ g, Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Sakarya University Medical Faculty, Sakarya, Turkey. Tel.: +90 264 255 21 06 13; Fax: +90 264 255 21 05; E-mail: drsinemyamac@yahoo.com. ogy [1]. The onset of the disease is usually in the most 5 productive ages of the life and it causes severe disabil- 6 ity at least in 1/3 of the patients. During the progress 7 of the disease, complaints like pain, fatigue and limited 8 mobility impair significantly the quality of life of the 9 patients [2]. 10 Ankylosing spondylitis (AS) is a chronic inflamma- 11 tory disease involving the joints and entheses. It af- 12 fects the patients usually in the second decade of their 13 life while they are building their careers. Although 14 ISSN 1053-8127/18/$35.00 c  2018 – IOS Press and the authors. All rights reserved uncorrected proof version