© January 2018 | IJIRT | Volume 4 Issue 8 | ISSN: 2349-6002 IJIRT 145257 INTERNATIONAL JO URNAL OF INNOVATIVE RESEARCH IN TECHNOLOGY 212 Structural Characterization and Bio-Activity Study of Schiff Base Metal Complexes C R Routray 1 , D Bhatta 2 , S K Biswal 3 1, 2, 3 Department of Chemistry, School of Applied Sciences, Centurion University of Technology and Management, Bhubaneswar, Odisha Abstract- The structural modification of organic molecules has considerable biological relevance and co- ordination of these compounds to metal ions significantly alters their biological activity. With this views , some Schiff base ligands are synthesized by the condensation of unsub/sub. aminothiazole with salicyl/napthyl aldehyde and their metal complexes with trasition metals. Cu(II),Ni(II),Zn(II) and Co(II) are prepared by adopting earlier procedure1. The complexes are characterized by elemental analysis, spectral study as well as by magnetic moment measurement. The structural elucidation of the molecules is based on electronic, IR, NMR as well as Magnetic Susceptibility measurement. The data are indicative of the fact that metal is bonded to ligand through phenolic oxygen and imino nitrogen atom. The anti-microbial assay of the prepared samples are carried out by adopting modern protocol and found to be good antibacterial and antifungal agents2. Index Terms- unsub/sub, thiazole, salicyl/napthyl aldehyde, transition metal complexes, Schiff base derivatives, spectral study, antimicrobial assay. INTRODUCT ION The discovery of novel active molecules against new target is a matter of urgency to overcome the alarming problem of microbial resistance to antibiotics. With the developing knowledge on properties of functional groups nature of the donor atoms, the central metal ion, ligand with imine/azomethine groups are used for complexion studies. Especially tetra dentate Schiff base with N2O2 donors are well known to co-ordinate with many metal ions and their complexes play an important role in biological, chemical and analytical fields1.It has been reported by many workers2 that Organic molecules complexes with metal ions exhibit better biological activity compared to compound alone, hence are used as effective drugs3-5. Henery et. al4 have synthesized some Schiff bases and their transition metal complexes with Cu(II),Ni(II) & Zn(II) and reported their biological activity. Metal complexes of some Schiff base derivatives have been prepared by Nair et al.1 and their antimicrobial activity against some clinically important bacteria is reported1. Synthesis, characterization and fungicidal activity of some quinazalone derivative has been studied by pattanaik et al.2 and found to be good fungicidal agents. The present work aims to prepare, characterize and study the antimicrobial and antifungal activities of some metal complexes derived from Schiff base ligands and transition metals by adopting modern techniques5-7. EXPERIM ENTA L The chemicals used were of A.R grade and doubled distilled water was used throughout the experiment. Purity of the ligands as well the complexes was checked by TLC and HPLC study. SYNTHESIS OF SCHIFF BASE LIGANDS Mixture of derivatives of amino thiazole(1 mole) , Sub./Unsub, Salicyl/Napthyl aldehyde (1 mol) in ethanol(30-35mL) and piperidine (3-4 drops) was refluxed on a water bath for about 1hr.After completion of the reaction, the product was cooled, filtered and recrystallized from ethanol8. SYNTHESIS OF METAL COMPLEXES The prepared ligands in benzene was added to solution of different metal acetates(0.5 mol)in