Research Journal of Pharmacognosy and Phytochemistry. 12(4): October - December, 2020 245 ISSN 0975-2331 (Print) 0975-4385 (Online) DOI: 10.5958/0975-4385.2020.00041.2 Vol. 12 |Issue-04| October-December| 2020 Available online at www.anvpublication.org Research Journal of Pharmacognosy and Phytochemistry Home page www.rjpponline.org REVIEW ARTICLE Neem: As a Natural Medicine *Corresponding Author E-mail: ABSTRACT: Neem (Azadirachta indica) is a member of the Meliaceae family. It serves as the Health-promoting Effect because it is rich source of Anti-oxidant. Neem is very important medicinal plant which is used to treat different diseases in Unani System of Medicine as well as traditional system of medicine (Ayurveda, Homeopathic Chinese and European ‘Materia Medica’). It is fast growing popular tree found in Africa, America and especially Indian subcontinent. Neem is considering harmless to humans, animals, and birds and has been approved by the US Environmental Protection Agency. All parts of the neem tree- leaves, flowers, seeds, fruits, roots and bark have been used traditionally for the treatment of inflammation, infections, fever, skin diseases and dental disorders. Azadirachtin and other active ingredients in the neem seed have insecticidal properties. Neem has been extensively used in Ayurveda, Unani and Homeopathic medicine. It contains many medicinal values and some biological activities like use in treatment of anti-allergic, anti-dermatic, anti-viral, anti-malarial, anti-fungal and anti-bacterial. It helps in the strong immunity and used in some inflammatory skin disorders. It has rightly been called as a “Single Solution to A Thousand Problems”. KEYWORDS: Neem, Azadirachta indica, Anti-oxidant, Ayurveda, Unani, Azadirachtin. 1. INTRODUCTION: Neem (Azadirachta indica) is fast growing evergreen popular tree and has been used in Ayurvedic medicine for more than 4000 years due to its medicinal properties [1]. Neem is a large found wild and often cultivated in India. The plant product or natural products shows an important role in diseases prevention and treatment through the enhancement of antioxidant activity, inhibition of bacterial growth and modulation of genetic pathways [2]. Neem is called ‘Arishta’ in Sanskrit word that means “reliever of sickness” [3]. It is typically grown in tropical and semi-tropical regions. The height of the tree is about 12 meters to 15 meters and rarely 25- 35 m. Received on 06.09.2020 Modified on 26.09.2020 Accepted on 12.10.2020 ©AandV Publications All right reserved Res. J. Pharmacognosy and Phytochem. 2020; 12(4):245-255. DOI: 10.5958/0975-4385.2020.00041.2 It is a flowering plant and normally starts fruiting after 3- 5 years. The tree becomes productive within 10 years [4]. The neem tree develops into a substantial shade tree with a thick, round canopy and can live for 150-200 years [5]. All the part of the tree is bitter in taste. The neem tree is an incredible plant that has been declared the “Tree of the 21st century” by the United Nations. The US National Academy of Science published a report in 1992 entitled “Neem: A tree for solving global problems” [3]. The therapeutics role of number of plants in disease management is still being enthusiastically researched due to their less side effect and affordable properties. It has been accepted that drugs based on allopathy are expensive and also exhibit toxic effect on normal tissues and on various biological activities [2]. Traditionally, the leaves and their paste are used for curing allergic skin reactions and antivirally treating smallpox and chicken pox. It is a largely accepted fact that numerous pharmacologically active drugs are utkarshbhamare48@gmail.com, yogeshmali3350@gmail.com Utkarsh U. Bhamare*, Yogesh Mali*, Azam Z. Shaikh