International Journal of Medical Science and Clinical Invention 10(11): 6951-6955, 2023 DOI:10.18535/ijmsci/v10i11.01 https://valleyinternational.net/index.php/ijmsci 6951 International Journal of Medical Science and Clinical Invention, vol. 10, Issue 11, November 2023 Original Article, The Analysis of the Correlations between Quantitative HBsAG Level, Virological Markers, and Histopathological Findings in Patients with Chronic Hepatitis B Özcan Deveci 1 Çiğdem Mermutluoğlu 2 , Muhammed Bekcibaşı 3 , Serkan Cerrah 4 , Alicem Tekin 5 , Mustafa Kemal Çelen 2 1 Genesis Hospital, Department of Infectious Diseases and Clinical Microbiology, Diyarbakır, Turkey 2 Dicle University Medical Faculty, Department of Infectious Diseases and Clinical Microbiology, Diyarbakir, Turkey 3 Health SciencesUniversity, Gazi Yaşargil Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Diyarbakir, Turkey 4 Health Sciences University, Erzurum Regional Training and Research Hospital, Department of Gastroenterology, Erzurum, Turkey 5 Health SciencesUniversity, Gazi Yaşargil Training and Research Hospital, Department of Medical Microbiology, Diyarbakir, Turkey E-mailAddress: ozcandeveci1@hotmail.com Abstract: Introduction: We aimedto analyze the correlations between serum HBsAg quantification (qHBsAg) level and virological properties in chronic hepatitis B (CHB) patients. Materials and Methods: The study was conducted with 53 CHB patients who underwent liver biopsy. Demographic characteristics of patients, biochemical parameters, serum qHBsAg levels, liver biopsy, and histopathology were assessed retrospectively. Results: A total of 53 patients were included in the study the mean patient age was 28,7 ± 8.1 and 34 (64.2%) were male. The mean patient qHBsAg was 631.4 ± 431.5, fibrosis score was 1,35 ± 0.87, ALT index score was 67.1 ± 53.4, and histologic activity index (HAI) score was 4,54 ± 1.55. In the statistical analysis, it was determined that there were negative correlations between the serum qHBsAg level and the HBV DNA level (r: -0,618, P<0.001), fibrosis score (r: -0,273, P: 0.048), ALT (rho: -0,489, P<0.001), and HAI index scores (r: -363, P: 0.008), while there was a positive correlation with the HBeAg positivity (rho: 0.445, p: 0.001). Conclusion: There were negative correlations between the qHBsAg level and virological (HBV DNA level), histopathological (fibrosis score, HAI index) findings, and a positive correlation with serological (HBeAg positivity) findings. Keywords: Quantitative, qHBsAg, Hepatitis B, Chronic hepatitis. Introduction: In the clinical prognosis in Chronic hepatitis B (CHB) patients, the follow-up of hepatitis B surface antigen (HBsAg), hepatitis B envelop antigen (HBeAg)seroconversion, Hepatitis B virus (HBV) DNA, and aminotransferase levels guide the physicians [1] . Early diagnosis of serious liver disease may improve the status of the disease even in patients who develop decompensation with treatment [2] . However, noninvasive tests are insufficient to determine liver disease to a certain level [3] . Thus, new diagnostic methods are required to diagnose liver fibrosis in the early period. Among these methods, there is a rising interest in the clinical determination of serum HBsAg quantification (qHBsAg) inrecent years due to the standardization of automatic systems [4,