JOURNAL OF CLINICAL AND BIOMEDICAL SCIENCES CASE REPORT OPEN ACCESS Received: 12.11.2023 Accepted: 06.12.2023 Published: 27.12.2023 Citation: Santhosha K, Manjunath GN, Abhay KK. Uninvited Guest in the H ouse: A Rare Case of Metastatic Gallbladder Cancer. J Clin Biomed Sci 2023; 13(4): 133-135. https://doi.org/ 10.58739/jcbs/v13i4.23.8 * Corresponding author. santhoshak168@gmail.com Funding: None Competing Interests: None Copyright: This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Sri Devaraj Urs Academy of Higher Education, Kolar, Karnataka ISSN Print: 2231-4180 Electronic: 2319-2453 Uninvited Guest in the H ouse: A Rare Case of Metastatic Gallbladder Cancer Santhosha Kulal 1* , Manjunath G N 2 , Abhay K Kattepur 3 1 Senior Resident, Department of Radiation Oncology, SDUMC, Kolar, Karnataka, India 2 Associate Professor and Head, SDUMC, Kolar, Karnataka, India 3 Associate Professor, Department of surgical oncology, SDUMC, Kolar, Karnataka, India Abstract Gallbladder cancer is a rare malignancy. About 1–2% of surgical specimens demonstrated a gallbladder cancer as an incidental finding. Metastasis to ovaries by biliary origin, known as Krukenberg tumour, though known, is infrequent. It can mimic clinically and morphologically, as a primary ovarian tumour challenging the diagnosis. Diagnosis of secondary ovarian tumours though its challenging often misdiagnosed as primary ovarian cancer, specifically mucinous adenocarcinomas. The distinction from the latter is essential, as it requires different treatment. Immunohistochemistry plays an important role in distinguishing primary ovarian tumours from extra- ovarian metastases. Detailed diagnostic laparotomy with examination of upper abdomen , IHC and UGI scopy evaluation plays a major role in identifying the primary tumour and make the correct diagnosis. As treatment varies according to primary, detailed evaluation might help in deciding appropriate palliative chemotherapy. Keywords: Krukenberg tumour; Gall bladder cancer; Immunohistochemistry; UGI scopy; Metastatic gallbladder cancer; Ovarian metastasis; Ovarian mass Introduction Gallbladder cancer is a rare malignancy. Oſten it is detected as an incidental finding on imaging or aſter a surgi- cal procedure. About 1–2% of surgi- cal specimens demonstrated a gallblad- der cancer as an incidental finding 1 . Most patients are oſten asymptomatic at presentation. Hence most of them are locally well advanced or metastatic at diagnosis. e tumour is thought to spread via lymphatic, hematogenous or trans-coelomic pathway. Metasta- sis to ovaries by biliary origin, known as Krukenberg tumour, though known, is infrequent. Only a few cases have been reported 2 .It can mimic clinically and morphologically, as a primary ovarian tumour challenging the diagnosis. Due its rarity in these belt, here we report a patient with metastatic gallbladder carci- noma. J Clin Biomed Sci 2023;13(4):133–135 133