First GWAS on Alzheimer’s Disease in Argentina and Chile populations Maria Carolina Dalmasso* 1 , Itziar de Rojas* 2,3 , Natividad Olivar 4 , Carolina Muchnik 4 , Bárbara Angel 5,6 , Sergio Gloger 7,8 , Mariana Soledad Sanchez Abalos 9 , M.Victoria Chacón 7 , Rafael Aránguiz 7,10 , Paulina Orellana 11,12,13 , Carolina Cuesta 14 , Pablo Galeano 15 , Lorenzo Campanelli 15 , Gisela Vanina Novack 15 , Luis Eduardo Martinez 14 , Nancy Medel 1,16 , Julieta Lisso 1,16 , Zulma Sevillano 1,16 , Nicolás Irureta 1,16 , Eduardo Miguel Castaño 15 , Laura Montrreal 2 , Michaela Thoenes 17 , Claudia Hanses 18 , Stefanie Heilmann-Heimbach 19 , Claudia Kairiyama 14 , Ines Mintz 1,16 , Ivana Villella 1,16 , Fabiana Rueda 20 , Amanda Romero 20 , Nancy Wukitsevits 16 , Ivana Quiroga 16 , Cristina Gona 16 , EADB, Jean-Charles Lambert 21 , Patricia Solis 1,16 , Daniel Gustavo Politis 14 , Carlos Alberto Mangone 22 , Christian Gonzalez- Billault 23,24 , Mercè Boada 2,3 , Lluís Tàrraga 2,3 , Andrea Slachevsky 23,25,26,27 , Cecilia Albala 5 , Patricio Fuentes 28,29 , Silvia Kochen 1 , Luis Ignacio Brusco 4 , Agustín Ruiz 2,3,+ , Laura Morelli 15,+ , Alfredo Ramírez 17,30,31,32,33,+ 1 Studies in Neuroscience and Complex Systems Unit-CONICET-HEC-UNAJ, Argentina 2 Research Center and Memory Clinic. Ace Alzheimer Center Barcelona – Universitat Internacional de Catalunya, Spain 3 CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain 4 Center of Neuropsychiatry and Behavior Neurology, School of Medicine, University of Buenos Aires, Argentina 5 Public Health Nutrition Unit, Institute of Nutrition and Food Technology, University of Chile, Chile, 6 Interuniversity Center for Healthy Aging RED21993 7 Biomedica Research Group, Centro de Estudios Clínicos, Santiago, Chile 8 Departamento de Psiquiatría y Salud Mental, Campus Oriente, Facultad de Medicina, Universidad de Chile, Santiago, Chile 9 Servicio De Diabetes y Metabolismo , Hospital Regional de Ushuaia ,Tierra del Fuego,Argentina 10 Instituto Nacional de Geriatría, Santiago, Chile 11 Geroscience Center for Brain Health and Metabolism, Chile 12 Latin American Institute for Brain Health (BrainLat), Universidad Adolfo Ibanez. Santiago, Chile 13 Center for Social and Cognitive Neuroscience (CSCN), School of Psychology, Universidad Adolfo Ibanez. Santiago, Chile 14 Hospital Interzonal General de Agudos-Eva Perón, Argentina 15 Laboratory of Brain Aging and Neurodegeneration. Fundacion Instituto Leloir-IIBBA, Argentina 16 Asistencia Medica Integral, Hospital El Cruce, Argentina 17 Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany 18 Department of Psychiatry and Psychotherapy, University Hospital of Bonn, Bonn, Germany 19 Institute of Human Genetics, University Hospital of Bonn & University of Bonn, Bonn, Germany 20 Imaging Diagnostics Service, Hospital El Cruce, Argentina 21 Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France 22 Hospital General de Agudos Donación Francisco Santojanni, Argentina 23 Faculty of Sciences. University of Chile 24 Geroscience Center for Brain Health and Metabolism 25 Neuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Department - Intitute of Biomedical Sciences (ICBM), Neurocience and East Neuroscience Departments, Faculty of Medicine, University of Chile, Santiago, Chile 26 Memory and Neuropsychiatric Center (CMYN), Memory Unit - Neurology Department, Hospital del Salvador and Faculty of Medicine, University of Chile, Santiago, Chile 27 Departamento de Neurología y Psiquiatría, Clínica Alemana-Universidad del Desarrollo. Santiago, Chile 28 Geriatrics Section Clinical Hospital University of Chile, Chile . CC-BY-NC-ND 4.0 International license It is made available under a perpetuity. is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint The copyright holder for this this version posted January 18, 2023. ; https://doi.org/10.1101/2023.01.16.23284609 doi: medRxiv preprint NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.