Neuroscience & Medicine, 2024, 15, 1-22 https://www.scirp.org/journal/nm ISSN Online: 2158-2947 ISSN Print: 2158-2912 DOI: 10.4236/nm.2024.151001 Jan. 15, 2024 1 Neuroscience & Medicine Neurocognitive Profile of People Living with Human Immunodeficiency Virus Initiating Treatment in Kinshasa in the Dolutegravir Era, Democratic Republic of Congo Candide About Kabamba 1 , Berry Ikolango Bongenya 2,3 , Jocelyn Ewuti Nonga 1 , Lambert Omombo Losenga 3 , Noëlla Maketi Dikati 3 , Thérèse Kasaka Ntumba 3 , Grace Ipaya Booto 3 , Rosalie Djamba Dembo 3 , Stéphanie Mauwa Selenge 3 , Benoit Obel Kabengele 4 , Guy Makila Mabe Bumoko 1 , Marie-Thérèse Ayane Safi Sombo 1* , Erick Ntambwe Kamangu 3,5* 1 Department of Neurology, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo 2 Faculty of Medicine, Bel Campus Technological University, Kinshasa, Democratic Republic of Congo 3 “Focus HIV/AIDS” Research Group, Kinshasa, Democratic Republic of Congo 4 Department of Internal Medicine, University Clinic of Kinshasa, Kinshasa, Democratic Republic of Congo 5 Molecular Biochemistry Department, Department of Basic Sciences, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo Abstract Context: Antiretroviral therapies improve the prognosis of NeuroAIDS con- trasting with a high frequency of Minor Neurocognitive Disorders (MND) even in aviremic subjects. Objective: The objective of this study is to present the neurological and cognitive profile of People Living with HIV (PLHIV) in- itiating antiretroviral treatment in Kinshasa in the era of Dolutegravir (DTG). Methods: This is a multicenter, cross-sectional study with a descriptive aim carried out in 16 HIV Outpatient Treatment Centers (OTC) in Kinshasa from October 4, 2021 to February 15, 2022. The International HIV Dementia Scale (IHDS) correlated with the Activities of Daily Living (IADL) scale facilitated the categorization of NeuroCognitive Disorders (NCD) of PLHIV evaluated after carrying out a summary neurological examination. Results: Of the 96 patients recruited, 56.3% were women with a sex ratio of 0.68. The average age was 40.1 ± 12.1 years. The secondary education level was the majority at 64.6%. Malaria (44.8%) and tuberculosis (32.3%) were more common as op- portunistic infections. They were alcoholics in (30.2%). Their history was heart disease (15.6%), high blood pressure (18.8%); drug abuse (10.4%). The IHDS score was light in 55.2% of cases. The correlation between IHDS/IADL How to cite this paper: Kabamba, C.A., Bongenya, B.I., Nonga, J.E., Losenga, L.O., Dikati, N.M., Ntumba, T.K., Booto, G.I., Dembo, R.D., Selenge, S.M., Kabengele, B.O., Bumoko, G.M.M., Sombo, M.-T.A.S. and Kamangu, E.N. (2024) Neurocognitive Pro- file of People Living with Human Immuno- deficiency Virus Initiating Treatment in Kin- shasa in the Dolutegravir Era, Democratic Republic of Congo. Neuroscience & Medi- cine, 15, 1-22. https://doi.org/10.4236/nm.2024.151001 Received: September 26, 2023 Accepted: January 12, 2024 Published: January 15, 2024