_____________________________________________________________________________________________________ *Corresponding author: E-mail: chinedubd@yahoo.com; J. Med. Health Res., vol. 9, no. 1, pp. 9-16, 2024 Journal of Medicine and Health Research Volume 9, Issue 1, Page 9-16, 2024; Article no.JOMAHR.11852 ISSN: 2456-9178 Association between Stress and Erectile Dysfunction among Adult Patients in a Tertiary Center in Nigeria Bede C. Azudialu a* , Ahaiwe Vivien b , Ndubueze Uchenna b , Ogunnaya Francis Ugonna c , Nkem Benjamin d and Nnadozie Raymond Ikechukwu Austin e a Department of Family Medicine, Federal University Teaching Hospital Owerri, Nigeria. b Department of Family Medicine, Federal Medical Centre Umuahia, Nigeria. c Department of Internal Medicine, Newark Beth Israel Medical Centre, Newark NJ, USA. d Research Unit, Federal University Teaching Hospital Owerri, Nigeria. e Department of Biology, Federal University of Technology, Owerri, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.56557/JOMAHR/2024/v9i18493 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://prh.ikprress.org/review-history/11852 Received: 10/11/2023 Accepted: 14/01/2024 Published: 23/01/2024 ABSTRACT Erectile dysfunction (ED) is a complex disorder with a biopsychosocial etiology that causes chronic stress on the individual thereby worsening the outcome of the disorder. The aim of this study is to establish an association between stress level and erectile dysfunction among adult patients presenting in the general outpatient of our tertiary hospital. A cross sectional study involving 421 adult males selected by simple random sampling was conducted using the International Index of Erectile Dysfunction (IIEF-5) and the Modified Percieved Stress Scale (PSS-10) Among the respondents, 219(52%) had ED while a greater proportion of those who had ED had mild ED 109 (49.8%). The other factors associated with ED on bivariate analysis include tobacco use (p < 0.05), alcohol intake (p < 0.05), diabetes mellitus, hypertension, use of anti hypertensive drugs, use of oral Original Research Article