~ 1736 ~ International Journal of Chemical Studies 2019; 7(2): 1736-1739 P-ISSN: 2349–8528 E-ISSN: 2321–4902 IJCS 2019; 7(2): 1736-1739 © 2019 IJCS Received: 24-01-2019 Accepted: 26-02-2019 S Dash Ph.D. in Veterinary Gynaecology and Obstetrics. Department of Veterinary Gynaecology and Obstetrics, Faculty of Veterinary and Animal Sciences, West Bengal University of Animal & Fishery Sciences Kshudiram Bose Sarani, Kolkata, West Bengal, India S Basu Professor, Department of Veterinary Gynaecology and Obstetrics, Faculty of Veterinary and Animal Sciences, West Bengal University of Animal & Fishery Sciences, Kshudiram Bose Sarani, Kolkata, West Bengal, India PC Mishra Professor, Department of Veterinary Gynaecology and Obstetrics, Faculty of Veterinary and Animal Sciences, West Bengal University of Animal & Fishery Sciences, Kshudiram Bose Sarani, Kolkata, West Bengal, India K Ray Professor, and Head, Department of Veterinary Gynaecology and Obstetrics, Faculty of Veterinary and Animal Sciences, West Bengal University of Animal & Fishery Sciences, Kshudiram Bose Sarani, Kolkata, West Bengal, India Correspondence S Dash Ph.D. in Veterinary Gynaecology and Obstetrics. Department of Veterinary Gynaecology and Obstetrics, Faculty of Veterinary and Animal Sciences, West Bengal University of Animal & Fishery Sciences Kshudiram Bose Sarani, Kolkata, West Bengal, India Effect of immunomodulators on certain haematological parameters in ameliorating bovine Endometritis S Dash, S Basu, PC Mishra, K Ray Abstract In the present investigation seventy two endometritic cows selected from some parts of Odisha and West Bengal after meticulous screening and were allotted randomly into six equal groups (n=12). Group I, II and III animals were administered with 100μg of E. coli LPS (LPS), 500 mg of oyster glycogen (OG), and 1000 mg enrofloxacin through i.u route after reconstituted with 30 milliliter of Phosphate Buffer Saline (PBS). Oral herbal drugs were used in group IV animals. In group V, 50 ml of normal saline was infused i.u. Endometritis animals receiving no treatments were considered as control for the study. Blood sample was collected from experimental cows prior to institution of therapy, 24 hrs after treatment and at next Estrus for evaluation of different haematological parameters. Use of immunomodulators improved Hb concentration Significantly (p < 0.05) at post treatment succeeding estrous. A significantly lower (p < 0.05) mean TLC value was observed at succeeding estrus in group I and II than other treatment groups. mean Nutrophil value at 24 hrs of treatment increased significantly (p < 0.05) from pretreatment value and it decreased significantly at the next succeeding etrous. Keywords: Endometritis, cows, immunomodulators, haematology Introduction Repeat breeding is one of the major problems affecting reproductive efficiency. The repeat breeding syndrome is a major source of economic waste and poor reproductive performance in dairy herds. The presence of clinical and Subclinical Endometritis (SE) is one of the etiological factors of repeat breeding syndrome. Endometritis is termed as the inflammation of endometrium and underlying glandular tissue without any systemic signs, occurring at least 21 days after calving (Sheldon et al., 2006) [1] . Uterine infections are observed following twin births, dystocia and surgical interventions employed to aid in cases of dystocia, retention of fetal membrane, stillbirth, prolapse of uteri, artificial insemination, copulation, and the use of intrauterine irritants. The inflammatory and immune response to uterine bacterial infection compromises animal welfare as well as cause subfertility and infertility (Sheldon et al., 2004) [2] . Dysfunction of cell immunity coexisting with subclinical Endometritis may be the main factor causing advanced inflammation of the uterus. There are substantial changes in subpopulations of immune cells in cows with subclinical Endometritis. Local mechanisms of uterine immunity vary from general immune mechanisms, the evidence of which are differences in the percentages of leukocyte subpopulations between uterus and peripheral blood of cows and possession of a lower phagocytic activity of uterine phagocytes than blood phagocytes. Knowledge of immunological mechanisms in the uterus of cows during subclinical Endometritis should enable more precise diagnosis of uterine inflammatory reactions and may be helpful in choosing proper adjuvant therapy with Immunomodulating agents. Immunomodulators are the new approach in treating Endometritis. They play their role to minimize infection by enhancing both systemic and local immunity through proliferating Certain body components lymphocytes, neutrophils, monocytes, humoral antibodies and PMN cells (Singh et al., 2001) [3] Materials and Method A total number of seventy two Endometritis affected cows were selected after screening and were allotted randomly into six equal groups having 12 animals in each group. Group I and II