Original article Antifungal susceptibilities of Candida species isolated from urine culture Türkan Toka € Ozer a, * , Süleyman Durmaz b , Erkan Yula c a Mevlana University, Faculty of Medicine, Department of Medical Microbiology, Konya, Turkey b Konya Numune Hospital, Microbiology Laboratory, Konya, Turkey c Katip Çelebi University, Faculty of Medicine, Department of Medical Microbiology, _ Izmir, Turkey article info Article history: Received 29 December 2015 Received in revised form 13 June 2016 Accepted 29 June 2016 Available online xxx Keywords: Candida Urinary tract infection Antifungal susceptibility Candiduria abstract Candida spp. are the most common opportunistic mycosis worldwide. Although Candida albicans is the most common cause of urinary tract infections, the frequency of non-albicans Candida species is increasing with common use of antifungal in the prophylaxis and treatment. This may lead to difficulties in treatment. Antifungal tests should be applied with identification of species for effective treatment. In this study, identification of Candida species isolated from urine culture and investigation of susceptibility of these strains to amphotericin B, flucytosine, fluconazole, voriconazole was aimed. In this study, 58 Candida strains isolated from urine cultures at Osmaniye State Hospital between January 2012 and April 2013 were included. Urine culture and antifungal susceptibility tests were applied. Incidence rate of Candida spp. was determined as C. albicans (56.9%), Candida glabrata (20.6%), Candida tropicalis (10.3%), Candida parapsilosis (7%), Candida krusei (3.4%), Candida kefyr (1.8%). Most of the isolates were susceptible to amphotericin B, flucytosine, fluconazole, voriconazole. Twenty three (39.7%) Candida strains were isolated from internal medical branches and Intensive Care Unit and 12 (20.6%) from the Surgical Medical Branches. C. albicans and C. glabrata species were isolated most frequently as a candiduria factor in this hospital between January 2012 and April 2013. The analysis of antifungal susceptibility profile shows no significant resistance to antifungals. © 2016 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. 1. Introduction Urinary tract infections (UTI) are the most common nosocomial infections. Although UTI are usually created by bacteria, a broad variety of fungi, the majority of UTI are caused by Candida spp. but Cryptococcus and Aspergillus spp. are also prevalent [1,2]. Candida are opportunistic pathogens commonly found in nature. Candida species constitutes about 10e15% of nosocomial UTI [3,4]. UTI caused by Candida species is increasing rapid in recent years depending on the surgical and medical applications. Especially diabetes mellitus, urinary system defects, chronic renal failure, neutopenia, use of broad-spectrum antibacterial drugs, corticoste- roids, immunosuppressive treatment and long-term urinary catheterization play important role in this rise [5,6]. In recent years, frequent use of antifungal prophylaxis and treatment results in infections with resistant non-albicans Candida species to antifun- gals [7]. Importance of antifungal susceptibility testing has increased to prevent or to minimize these problems. In this study, it was aimed to know the prevalence of Candida species that causing UTI and their antifungal susceptibility pattern. 2. Materials and methods In this study, 58 Candida strains isolated from urine cultures of hospitalized patients in Osmaniye State Hospital Microbiology Laboratory between January 2012 and April 2013. Male and female patients were considered for our study. Only in patients who pre- sented with signs and symptoms of urinary tract infections were included. Pure growth of yeast isolates with significant colony count was included in the study. The urine samples, where Candida species was isolated in the absence of pyuria, Candida with colony * Corresponding author. Department of Medical Microbiology, Mevlana Univer- sity, Faculty of Medicine, Yeni _ Istanbul Cad. No: 235, 42003 Selçuklu/Konya, Turkey. Fax: þ90 332 241 11 11. E-mail address: tozer73@hotmail.com (T. Toka € Ozer). Contents lists available at ScienceDirect Journal of Infection and Chemotherapy journal homepage: http://www.elsevier.com/locate/jic http://dx.doi.org/10.1016/j.jiac.2016.06.012 1341-321X/© 2016 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. J Infect Chemother xxx (2016) 1e4 Please cite this article in press as: Toka € Ozer T, et al., Antifungal susceptibilities of Candida species isolated from urine culture, J Infect Chemother (2016), http://dx.doi.org/10.1016/j.jiac.2016.06.012