_____________________________________________________________________________________________________ *Corresponding author: E-mail: Almoeiz7@gmail.com; Int. Neuropsy. Dis. J., vol. 21, no. 2, pp. 1-13, 2024 International Neuropsychiatric Disease Journal Volume 21, Issue 2, Page 1-13, 2024; Article no.INDJ.113223 ISSN: 2321-7235, NLM ID: 101632319 A Study on the Attitude, Abuse and Addiction to Tramadol among Sudanese University Students in Khartoum State, Sudan Mohamed I.A. Ismail a , Mohammed O.J. Almardi a , Mohammed M.A. Jabir a , Sara Lavinia Brair b , Intisar. A. Bashir c , Moneer A. Abdalla b and Almoeiz Y. Hammad d* a Sudan International University, Khartoum, Sudan. b Community Medicine Department, Al Neelain University, Khartoum, Sudan. c Pharmacognosy Department, Al Neelain University, Khartoum, Sudan. d Faculty of Medicine, Omdurman Ahlia University, Omdurman, Sudan. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/INDJ/2024/v21i2422 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/113223 Received: 17/12/2023 Accepted: 20/02/2024 Published: 22/02/2024 ABSTRACT Aim: This research was designed to study addiction to the drug Tramadol among university students in Khartoum State. Introduction: Tramadol is an atypical opioid that binds to μ-opioid receptors on neurons. It has a bioavailability of 70% and undergoes extensive first-pass metabolism in the liver. In most countries, it is a prescription-only medicine. Tramadol abuse has increased recently in the last few years Original Research Article